Results 111 to 120 of about 22,314 (260)

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Diversity of Plant Sterols Metabolism: The Impact on Human Health, Sport, and Accumulation of Contaminating Sterols. [PDF]

Nutrients, 2021
Kopylov AT, Malsagova KA, Stepanov AA, Kaysheva AL.   +3 more
europepmc   +1 more source

Differentiation of Plant and Animal‐Derived Cholesterol Using irm‐13C NMR and IRMS

Magnetic Resonance in Chemistry, EarlyView.
Determining and certifying the origin of ingredients, starting materials, and excipients used in manufactured goods like cosmetics and medicines can be difficult. In this report, we describe a robust approach for identifying the origin of cholesterol, a component of myriad consumer products using irm‐13C NMR and IRMS to differentiate plant versus ...
Anika M. Singh, Subir Chakraborty, Remington X. Poulin, R. Thomas Williamson   +3 more
wiley   +1 more source

Reassessing very long chain fatty acids elevations: Sitosterolemia as a non-peroxisomal cause

Molecular Genetics and Metabolism Reports
Very-long-chain fatty acids (VLCFAs) are commonly used to diagnose peroxisomal disorders, but elevated levels may also result from other non-peroxisomal causes, leading to diagnostic challenges.
Merve Yoldaş Çelik, Burcu Köşeci, Ezgi Burgaç, Kanay Yararbaş   +3 more
doaj   +1 more source

Dietary Plant Sterols and Phytosterol-Enriched Margarines and Their Relationship with Cardiovascular Disease among Polish Men and Women: The WOBASZ II Cross-Sectional Study. [PDF]

Nutrients, 2022
Witkowska AM, Waśkiewicz A, Zujko ME, Cicha-Mikołajczyk A, Mirończuk-Chodakowska I, Drygas W.   +5 more
europepmc   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Cross-Sectional Study of Plant Sterols Intake as a Basis for Designing Appropriate Plant Sterol-Enriched Food in Indonesia. [PDF]

Nutrients, 2021
Martianto D, Bararah A, Andarwulan N, Średnicka-Tober D.   +3 more
europepmc   +1 more source

The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children

Obesity, EarlyView.
ABSTRACT Objective The lipid droplet–associated hydrolase (LDAH) is a lipid droplet–associated protein with an uncharacterized role in human adipose tissue (AT) and obesity; we aimed to investigate its role in human AT and its relevance for childhood obesity.
Claudia Vales‐Villamarín, Antje Berthold, Martin Lacher, Antje Körner, Kathrin Landgraf   +4 more
wiley   +1 more source

Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV

Microbiology Spectrum
Non-cholesterol sterol metabolism plays a crucial role in immune regulation. However, the non-cholesterol sterol profiles, its association with gut dysbiosis, and its impact on the CD4+ T cell recovery in people living with HIV (PLWH) are yet to be ...
Jingying Pan, Xuebin Tian, Kai Wu, Jia Ji, Mingqing Dong, Ting Sun, Dan Lv, Peng Yao, Longxian Lv, Hangping Yao   +9 more
doaj   +1 more source