Results 111 to 120 of about 371,204 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Spatiotemporal DNA Endoploidy Map of the Arabidopsis Root Reveals Roles for the Endocycle in Root Development and Stress Adaptation

, 2018
© 2018 ASPB. Somatic polyploidy caused by endoreplication is observed in arthropods, molluscs, and vertebrates but is especially prominent in higher plants, where it has been postulated to be essential for cell growth and fate maintenance.
Boudolf, Veronique, Cuevas, Fabiola, Beeckman, Tom, Lu, R., Xu, F., Nowack, Moritz, Hofte, H., Smith, Richard S, Lambert, G., Van Isterdael, Gert, De Veylder, L., Smith, Richard, Vercauteren, Ilse, Kumpf, Robert P., Boudolf, V., Kumpf, R., Eekhout, Thomas, Nowack, Moritz K., De Rycke, R., Höfte, Herman, Cuevas, F., Maere, S., Larkin, J., De Rycke, Riet, Kremer, Anna, Xu, Fan, Galbraith, D., Lambert, Georgina M., Lambert, Georgina M, Smith, R., Smith, Richard S., Kremer, A., Nowack, M., Storme, V., Hu, Z., Storme, Veronique, De Veylder, Lieven, Vercauteren, I., Beeckman, T., Bhosale, Rahul, Galbraith, David W., Kumpf, Robert, Maere, Steven, Galbraith, David W, Cuevas Bustamante, Fabiola, Bhosale, R., Larkin, John C, Larkin, John C., Hu, Zhubing, Eekhout, T., Lu, Ran, Van Isterdael, G.   +51 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Deseeded Sunflower Fractions and Their Anatomy and Cell Morphology

BioResources
Deseeded sunflower is a heterogeneous lignocellulosic biomass that has not been well utilized due to the incomplete understanding of its biological structure.
Lizhen Wang, Junyue Wang, Xiaotian Li
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Induced disease resistance

, 2015
During the co-evolutionary arms race between plants and pathogens, plants evolved a sophisticated defense system to ward off their enemies. In this plant immune system, plant receptor proteins recognize non-self molecules of microbial origin, which leads
van Wees, Saskia, Sub Plant-Microbe Interactions, Pieterse, Corné, Lugtenberg, Ben, Plant Microbe Interactions   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Ethylene and auxin in the control of wood formation [PDF]

, 2003
This thesis considers aspects of the regulation of growth rate and fibre properties in forest trees. These properties are both genetically determined and influenced by environmental stimuli.
Jenny Maria Hellgren, Hellgren, Jenny Marie, Hellgren, Jenny Maria   +2 more
core  

Plant Tissues as Biomonitoring Tools for Environmental Contaminants

International Journal of Plant Biology
Environmental toxins pose significant threats to ecosystems and human health. Monitoring and assessing these toxins are crucial for effective environmental management and public health protection.
Mariam Tarish, Rania T. Ali, Muhammad Shan, Zarmeena Amjad, Qingchen Rui, Sayed Abdul Akher, Abdullah Al Mutery   +6 more
doaj   +1 more source