Results 151 to 160 of about 7,372,456 (333)

PATENTING LIFE FORMS: ISSUES SURROUNDING THE PLANT VARIETY PROTECTION ACT

open access: yes
Research and Development/Tech Change/Emerging Technologies,
Claffey, Barbara A.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Stages of national varietal plant recourses forming in the State Legislative Regulation system of Ukraine during 1923-2013

open access: yes, 2013
The article deals with analysis of scientific publications in the field of plant breeding, seed production and variety testing, archival documents and published government regulations.
П. М. Василюк
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The State Service on Right Protection for Plant Varieties activity at the present stage of development

open access: yes, 2006
The cost-effectiveness of examination institutions activity of the State System on Plant Variety Protection was developed on the macro level. At the present stage there is an urgent necessity to provide with general methods to solve the tasks of the ...
М. І. Кісіль   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Effects of Strengthened IPR Regimes on the Plant Breeding Sector in Developing Countries

open access: yes
This paper analyzes the effect of intellectual property rights (IPR) regimes on the plant breeding sector in developing countries. Most of these countries have implemented a system of plant variety protection (PVP), or are in the process of doing so ...
Eaton, Derek J.F.   +2 more
core  

Replenishment of the plant variety market: garden pea (Pisum sativum L.)

open access: yes, 2008
It is presented the description of garden pea new varieties which are included into the State Register of plant varieties, which are suitable for the dissemination in Ukraine in 2008 year, morphological features of the crop and its value, either food or ...
О. І. Безручко
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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