Results 171 to 180 of about 298 (198)

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Interaction of phloem proteins and viral factors involved in virus long distance movement in the plant

, 2011
Rodriguez Medina, Caren Dayana, Chapuis, Sophie, Sofer, Luc, Revers, Frédéric, Ziegler-Graff, Véronique, Brault, Veronique   +5 more
openaire   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

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Movement Profiles: A Tool for Quantitative Analysis of Cell-to-Cell Movement of Plant Viral Movement Proteins

Methods in Molecular Biology, 2008
Movement proteins (MPs) are virally encoded factors that mediate transport of viral nucleic acid between plant cells. Many MPs are able to move between cells themselves. This feature serves as the basis for evaluation of the transport activity of individual MPs.
Elisabeth Waigmann
exaly   +3 more sources

Interaction of Movement Proteins with Host Factors, Mechanism of Viral Host Cell Manipulation and Influence of MPs on Plant Growth and Development

2016
Even more than 100 years after Eduard Tangl first described plasmodesmata (PD) as “open communications” between protoplasts of endosperm cells (Carr 1976), the components of plasmodesmata as well as plasmodesmata-located proteins still remain enigmatic. Considering the fact, that this system is also co-opted by various plant viruses to enable the viral
Uwe Sonnewald, Sonnewald Uwe
exaly   +2 more sources

Plant Paralog to Viral Movement Protein That Potentiates Transport of mRNA into the Phloem

Science, 1999
CmPP16 from Cucurbita maxima was cloned and the protein was shown to possess properties similar to those of viral movement proteins. CmPP16 messenger RNA (mRNA) is present in phloem tissue, whereas protein appears confined to sieve elements (SE).
B, Xoconostle-Cázares, Y, Xiang, R, Ruiz-Medrano, H L, Wang, J, Monzer, B C, Yoo, K C, McFarland, V R, Franceschi, W J, Lucas   +8 more
openaire   +2 more sources

A dual-function movement protein regulates viral replication suppression and movement facilitation in plant viral infections

Plant Physiology
Abstract Viral replication and intracellular movement are essential and interdependent steps during plant viral infections. Mechanistic insights into each step have been established, but the regulatory interplay between these processes and their underlying molecular mechanisms remain poorly understood.
Shan Bu, Lujia Wang, Xiangwen Luo, Zina Lin, Yu Zhang, Shijun Li, Xiao Yang, Jian Wu, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Fei Yan, Deyong Zhang, Jiejun Peng, Songbai Zhang, Yong Liu   +16 more
openaire   +2 more sources

Viral Movement Proteins Induce Tubule Formation in Plant and Insect Cells

2006
Plant viruses move from cell to cell through plasmodesmata, which are complex gatable pores in the cell wall. As plasmodesmata normally allow the diffusion of only small molecules, virus movement is only achieved by the action of virus-encoded movement proteins that biochemically or structurally modify these pores to enable the passage of ‘naked’ viral
van Lent, J.W.M., Schmitt-Keichinger, C.
openaire   +3 more sources