Facilitating viral vector movement enhances heterologous protein production in an established plant system [PDF]
Plant Biotechnology Journal, 2022 Summary Molecular farming technology using transiently transformed Nicotiana plants offers an economical approach to the pharmaceutical industry to produce an array of protein targets including vaccine antigens and therapeutics.
Xu Wang +5 more
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Systemic spread of an RNA insect virus in plants expressing plant viral movement protein genes [PDF]
Proceedings of the National Academy of Sciences, 2001 Flock house virus (FHV), a single-stranded RNA insect virus, has previously been reported to cross the kingdom barrier and replicate in barley protoplasts and in inoculated leaves of several plant species [Selling, B. H., Allison, R. F. & Kaesberg, P. (1990)Proc. Natl. Acad. Sci. USA87, 434–438]. There was no systemic movement of FHV in plants.
Ranjit Dasgupta +2 more
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Suppression of a dsRNA-induced plant immunity pathway by viral movement protein [PDF]
, 2021 Summary The virome of plants is dominated by RNA viruses 1 and several of these cause devastating diseases in cultivated plants leading to global crop losses 2 .
Caiping Huang +4 more
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Two Plant–Viral Movement Proteins Traffic in the Endocytic Recycling Pathway [PDF]
The Plant Cell, 2004 Abstract Many plant viruses exploit a conserved group of proteins known as the triple gene block (TGB) for cell-to-cell movement. Here, we investigated the interaction of two TGB proteins (TGB2 and TGB3) of Potato mop-top virus (PMTV), with components of the secretory and endocytic pathways when expressed as N-terminal fusions to ...
Sophie Haupt +5 more
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The Unfolded Protein Response Is Triggered by a Plant Viral Movement Protein [PDF]
Plant Physiology, 2011 AbstractInfection with Potato virus X (PVX) in Nicotiana benthamiana plants leads to increased transcript levels of several stress-related host genes, including basic-region leucine zipper 60 (bZIP60), SKP1, ER luminal binding protein (BiP), protein disulfide isomerase (PDI), calreticulin (CRT), and calmodulin (CAM).
Changming Ye +4 more
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The cis‐expression of the coat protein of turnip mosaic virus is essential for viral intercellular movement in plants [PDF]
Molecular Plant Pathology, 2020 AbstractTo establish infection, plant viruses are evolutionarily empowered with the ability to spread intercellularly. Potyviruses represent the largest group of known plant‐infecting RNA viruses, including many agriculturally important viruses. To better understand intercellular movement of potyviruses, we used turnip mosaic virus (TuMV) as a model ...
Zhaoji Dai +3 more
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Small hydrophobic viral proteins involved in intercellular movement of diverse plant virus genomes
AIMS Microbiology, 2020 Most plant viruses code for movement proteins (MPs) targeting plasmodesmata to enable cell-to-cell and systemic spread in infected plants. Small membrane-embedded MPs have been first identified in two viral transport gene modules, triple gene block (TGB) coding for an RNA-binding helicase TGB1 and two small hydrophobic proteins TGB2 and TGB3 and double
Sergey Y. Morozov, Andrey G. Solovyev
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Risk‐managed production of bioactive recombinant proteins using a novel plant virus vector with a helper plant to complement viral systemic movement [PDF]
Plant Biotechnology Journal, 2010 SummaryA plant viral vector has the potential to efficiently produce recombinant proteins at a low cost in a short period. Although recombinant proteins can be also produced by transgenic plants, a plant viral vector, if available, may be more convenient when urgent scale‐up in production is needed.
Noriho Fukuzawa +6 more
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A plant virus-encoded protein facilitates long-distance movement of heterologous viral RNA [PDF]
Proceedings of the National Academy of Sciences, 1999 Transport of plant viruses from cell to cell typically involves one or more viral proteins that supply specific cell-to-cell movement functions. Long-distance transport of viruses through the vascular system is a less well understood process with requirements different from those of cell-to-cell movement. Usually viral coat protein (CP)
E. V. Ryabov +2 more
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Identification of a Functional Plasmodesmal Localization Signal in a Plant Viral Cell-To-Cell-Movement Protein [PDF]
mBio, 2016 ABSTRACT Our fundamental knowledge of the protein-sorting pathways required for plant cell-to-cell trafficking and communication via the intercellular connections termed plasmodesmata has been severely limited by the paucity of plasmodesmal targeting sequences that have been identified to date.
Yuan Cheng +2 more
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