From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Seroprevalence, Genetic Characteristics, and Pathogenicity of Korean Porcine Sapeloviruses
VirusesAlthough porcine sapelovirus (PSV) is generally subclinical, it can cause a wide range of clinical signs in some individuals, including respiratory distress, acute diarrhea, pneumonia, skin lesions, reproductive failure, and neurological diseases.
Song-Yi Kim +7 more
doaj +1 more source
Application of multivariate analysis to electrical penetration graphs using manual and automate waveform recognization from the planthopper Peregrinus maidis feeding on susceptible and resistant maize [PDF]
, 2004 The stylet penetration activities of Peregrinus maidis (Ashmead) (Homoptera: Delphacidae), vector of Maize mosaic virus (MMV) and Maize stripe virus (MStV) were studied by electrical penetration graphs (DC-EPG) on resistant and susceptible maize inbred ...
Buduca, Cécile +5 more
core
In vitro thermotherapy-based methods for plant virus eradication
Plant Methods, 2018 Production of virus-free plants is necessary to control viral diseases, import novel cultivars from other countries, exchange breeding materials between countries or regions and preserve plant germplasm.
Min‐Rui Wang +5 more
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
One-Enzyme RTX-PCR for the Detection of RNA Viruses from Multiple Virus Genera and Crop Plants
Viruses, 2022 Reverse transcription PCR (RT-PCR) is a popular method for detecting RNA viruses in plants. RT-PCR is usually performed in a classical two-step procedure: in the first step, cDNA is synthesized by reverse transcriptase (RT), followed by PCR amplification
Hana Hoffmeisterová +10 more
doaj +1 more source
Aphid transmission of Cauliflower mosaic virus: the role of the host plant [PDF]
, 2009 Addendum to: Martinière A, Gargani D, Uzest M, Lautredou N, Blanc S, Drucker M. A role for plant microtubules in the formation of transmission-specific inclusion bodies of Cauliflower mosaic virus. Plant J 2009; 58:135-46.
Drucker, Martin +2 more
core +4 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Geminivirus C2 protein represses genes involved in sulphur assimilation and this effect can be counteracted by jasmonate treatment [PDF]
, 2012 Geminiviruses are plant viruses that infect a broad range of crops and cause extensive losses worldwide, having an important economic impact. C2, a multifunctional pathogenicity factor encoded by geminiviruses, has been recently shown to suppress the ...
Balzergue, Sandrine +5 more
core +3 more sources
Frontiers in Plant Science, 2018 Positive-sense (+) RNA viruses represent the most abundant group of viruses and are dependent on the host cell machinery to replicate. One remarkable feature that occurs after (+) RNA virus entry into cells is the remodeling of host endomembranes ...
Xuejiao Jin +6 more
semanticscholar +1 more source