Results 341 to 350 of about 5,677,108 (410)

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

open access: yesAdvanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe   +4 more
wiley   +1 more source

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

open access: yesAdvanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang   +13 more
wiley   +1 more source

A plant virus manipulates the long-winged morph of insect vectors. [PDF]

open access: yesProc Natl Acad Sci U S A
Yu J   +8 more
europepmc   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

FMint: Bridging Human Designed and Data Pretrained Models for Differential Equation Foundation Model for Dynamical Simulation

open access: yesAdvanced Theory and Simulations, EarlyView.
FMint is introduced as a multi‐modal foundation model that integrates human‐designed solvers and data‐driven methods for fast, accurate simulation of dynamical systems. FMint leverages in‐context learning within a transformer‐based framework to refine coarse numerical solutions.
Zezheng Song, Jiaxin Yuan, Haizhao Yang
wiley   +1 more source

Pharmacology of a Plant Virus Immunotherapy Candidate for Peritoneal Metastatic Ovarian Cancer. [PDF]

open access: yesACS Pharmacol Transl Sci
Omole AO   +3 more
europepmc   +1 more source

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