Results 121 to 130 of about 5,712,318 (385)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The Plant Pathology Journal, 2020 The potential transmission of plant pathogenic viruses through processed foods could be a source of concern for global crop production; however, there is a lack of supporting evidence.
Seoyeon Ko +5 more
doaj +1 more source
Pyramiding of Ryd2 and Ryd3 conferring tolerance to a German isolate of Barley yellow dwarf virus-PAV (BYDV-PAV-ASL-1) leads to quantitative resistance against this isolate [PDF]
, 2011 Barley yellow dwarf virus (BYDV) is an economically important pathogen of barley, which may become even more important due to global warming. In barley, several loci conferring tolerance to BYDV-PAV-ASL-1 are known, e.g.
Broer, I. +5 more
core +2 more sources
Chemotherapy and Plant Viruses [PDF]
Journal of General Microbiology, 1953 SUMMARY: When the guanine analogue, 5-amino-7-hydroxy-1-v-triazolo (d) pyrimidine (guanazolo), was sprayed on the leaves of tobacco or Nicotiana glutinosa plants it reduced the number of local lesions and delayed or inhibited systemic spread of lucerne mosaic virus.
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Plant virus transmission during seed development and implications to plant defense system
Frontiers in Plant ScienceMost plants produce large amounts of seeds to disperse their progeny in the environment. Plant viruses have evolved to avoid plant resistance mechanisms and use seeds for their dispersal.
Cesar Escalante +7 more
doaj +1 more source
Aphids associated with shrubs, herbaceous plants and crops in the Maltese Archipelago (Hemiptera, Aphidoidea) [PDF]
, 2011 A survey of the aphids associated with Maltese shrubs, herbaceous plants and crops was carried out. Sixty six aphid species were recorded from more than 90 species of host plants.
Azzopardi, Erika +6 more
core
Potential and limitations of plant virus epidemiology: lessons from the Potato virus Y pathosystem [PDF]
, 2011 Plant virus epidemiology provides powerful tools to investigate key factors that contribute to virus epidemics in agricultural crops. When successful, epidemiological approaches help to guide decisions regarding plant protection strategies.
Döring, Thomas F.
core +1 more source
Ecogenomic survey of plant viruses infecting Tobacco by Next generation sequencing
Virology Journal, 2016 BackgroundThe invasion of plant by viruses cause major damage to plants and reduces crop yield and integrity. Devastating plant virus infection has been experienced at different times all over the world, which are attributed to different events of ...
Ibukun A. Akinyemi +4 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source