Results 111 to 120 of about 66,062 (256)

Functional magnetic resonance microscopy of long- and short-distance water transport in trees

, 2009
Due to their long life span, changing climatic conditions are of particular importance for trees. Climate changes will affect the water balance, which can become an important limiting factor for photosynthesis and growth. Long-distance water transport in
Homan, N.
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An analysis of the diurnal course of growth, carbon dioxide exchange and carbohydrate reserve content of cucumber

, 1977
A detailed study was made of the diurnal course of carbon dioxide exchange, transpiration and carbohydrate reserve levels in different organs of young cucumberplants, cultivated in climate rooms under 'spring' or 'winter' conditions.
Challa, H.
core  

Monitoring of soil EC for the prediction of soil nutrient regime under different soil water and organic matter contents

Applied Biological Chemistry
Smart farms and precision agriculture require automatic monitoring and supply of water and nutrients for crops, but sensors to monitor plant available nutrients in soil are not available.
Han Na Kim, Jin Hee Park
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Assessment of plant water status in winter wheat (Triticum aestivum L.) based on canopy spectral indices.

PLoS ONE, 2019
Rapid and non-destructive estimation of plant water status is essential for adjusting field practices and irrigation schemes of winter wheat. The objective of this study was to find new combination spectral indices based on canopy reflectance for the ...
Hui Sun, Meichen Feng, Lujie Xiao, Wude Yang, Chao Wang, Xueqin Jia, Yu Zhao, Chunqi Zhao, Saleem Kubar Muhammad, Deying Li   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Midday measurements of leaf water potential and stomatal conductance are highly correlated with daily water use of Thompson Seedless grapevines

, 2011
A study was conducted to determine the relationship between midday measurements of vine water status and daily water use of grapevines measured with a weighing lysimeter. Water applications to the vines were terminated on August 24th for 9 days and again
Williams, L.E., Vaughn, P., L. E. Williams, Baeza Trujillo, Pilar, P. Vaughn, P. Baeza   +5 more
core   +1 more source

Water Stress and Black Cutworm Feeding Modulate Plant Response in Maize Colonized by Metarhizium robertsii

Pathogens
Plants face many environmental challenges and have evolved different strategies to defend against stress. One strategy is the establishment of mutualistic associations with endophytic microorganisms which contribute to plant defense and promote plant ...
Imtiaz Ahmad, Maria del Mar Jimenez-Gasco, Mary E. Barbercheck   +2 more
doaj   +1 more source