Results 171 to 180 of about 2,251,238 (297)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Commodity risk assessment of <i>Petunia</i> spp. and <i>Calibrachoa</i> spp. unrooted cuttings from Uganda. [PDF]

EFSA J
EFSA Panel on Plant Health (PLH), Civera AV, Baptista P, Berlin A, Chatzivassiliou E, Cubero J, Cunniffe N, de la Peña E, Desneux N, Di Serio F, Filipiak A, Gonthier P, Hasiów-Jaroszewska B, Jactel H, Landa BB, Maistrello L, Makowski D, Milonas P, Papadopoulos NT, Susi H, van der Gaag DJ, Lacomme C, Debode J, Navas-Cortes JA, Akrivou A, Kritikos C, Kormpi M, Papachristos D, Reppa C, Antonatos S, Beris D, Schulz OM, Lombardo MF, Gardi C, Potting R.   +34 more
europepmc   +1 more source

The Type III-Dependent Hrp Pilus Is Required for Productive Interaction of Xanthomonas campestris pv. vesicatoria with Pepper Host Plants [PDF]

, 2005
E. Weber, Tuula Ojanen‐Reuhs, Elisabeth Huguet, Gerd Hause, Martin Romantschuk, Timo Korhonen, Ulla Bonas, Ralf Koebnik   +7 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Plant Root Architectural Traits Mediate a Trade-Off Between Suppression and Tolerance of Competitors. [PDF]

Ecol Evol
Salinas H, Veneklaas EJ, Trevenen E, Renton M.   +3 more
europepmc   +1 more source

An array of Zymoseptoria tritici effectors suppress plant immune responses [PDF]

Elisha Thynne, Haider Ali, Kyungyong Seong, Mohammad Abukhalaf, Marco Alexandre Guerreiro, Victor M. Flores‐Nunez, Rune Hansen, Ana Bergues, Maja J. Salman, J. J. Rudd, K. Kanyuka, Andreas Tholey, Ksenia V. Krasileva, Graeme J. Kettles, Eva H. Stukenbrock   +14 more
openalex   +1 more source

PLANT FUNCTIONAL TRAITS, ENVIRONMENTS AND ECOSYSTEM FUNCTIONING [PDF]

, 2007
MENG Ting-Ting
openalex   +1 more source

Eight generations of native seed cultivation reduces plant fitness relative to the wild progenitor population

, 2021
Riley B. Pizza, Erin K. Espeland, Julie R. Etterson   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants. [PDF]

NPJ Biol Timing Sleep
Kumimoto RW, Marshall CM, Zhang H, Harmer SL.   +3 more
europepmc   +1 more source