Results 71 to 80 of about 9,139,223 (407)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule
Frontiers in Molecular Biosciences, 2019 Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H+ or Na+ across membranes in a process that can be K+ dependent or independent.
Alexandra O. M. Holmes +3 more
doaj +1 more source
Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
Beilstein Journal of Organic Chemistry, 2022 The cytochrome P450 monooxygenase (CYP) superfamily comprises hemethiolate enzymes that perform remarkable regio- and stereospecific oxidative chemistry.
Karan Malhotra, Jakob Franke
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress
Molecules, 2019 Phenolic compounds are an important class of plant secondary metabolites which play crucial physiological roles throughout the plant life cycle. Phenolics are produced under optimal and suboptimal conditions in plants and play key roles in developmental ...
Anket Sharma +5 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
A Stimulatory Role for Cytokinin in the Arbuscular Mycorrhizal Symbiosis of Pea [PDF]
, 2019 The arbuscular mycorrhizal (AM) symbiosis between terrestrial plants and AM fungi is regulated by plant hormones. For most of these, a role has been clearly assigned in this mutualistic interaction; however, there are still contradictory reports for ...
Cosme, Marco +8 more
core +1 more source
Manufacturing Management Practices in the Western Balkans [PDF]
, 2020 In this report, we investigate the quality of management practices in manufacturing plants in the Western Balkans. In particular, we focus on modern operations, quality of monitoring, target setting and talent management.
Cerar, Jelena, Nell, Phillip C.
core
Na+ tolerance and Na+ transport in higher plants.
Annals of Botany, 2003 Tolerance to high soil [Na(+)] involves processes in many different parts of the plant, and is manifested in a wide range of specializations at disparate levels of organization, such as gross morphology, membrane transport, biochemistry and gene ...
M. Tester, R. Davenport
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source