Results 291 to 300 of about 575,333 (346)

Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability.

Atherosclerosis, 2020
Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from 15 μm to 1 mm in ...
H. Jinnouchi, Y. Sato, A. Sakamoto, A. Cornelissen, M. Mori, R. Kawakami, N. Gadhoke, F. Kolodgie, R. Virmani, A. Finn   +9 more
semanticscholar   +1 more source

Devouring atherosclerotic plaques

Nature Nanotechnology, 2020
Targeting of local macrophages by functionalized carbon nanotubes enables efferocytosis and clearance of atherosclerotic plaques.
openaire   +2 more sources

Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy.

Journal of Controlled Release, 2020
Atherosclerosis is a kind of chronic inflammatory diseases characterized by dysfunction of local immune responses. Here we engineer platelet-derived extracellular vesicles (PEVs) to load MCC950, an NLRP3-inflammasome inhibitor, for atherosclerosis ...
Qingle Ma, Qin Fan, Xiao Han, Z. Dong, Jialu Xu, Jinyu Bai, Weiwei Tao, Dongdong Sun, Chao Wang   +8 more
semanticscholar   +1 more source

Imaging of atherosclerotic plaque

The International Journal of Cardiovascular Imaging, 2004
The behavior and composition of coronary atherosclerotic plaques are ultimately responsible for the threat of acute ischemic events in patients with coronary artery disease. Different imaging modalities have been developed over the last several years in order to better characterize the atherosclerotic plaque and attempt to predict those in peril of ...
Mario A, Pulido, Dominick J, Angiolillo, Marco A, Costa   +2 more
openaire   +2 more sources

Effect of statins on atherosclerotic plaque.

Trends in cardiovascular medicine, 2019
Lipid lowering therapy has been the mainstay of cardiovascular risk reduction and prevention. Statin drugs have been shown to reduce serum cholesterol along with significant reduction in morbidity and mortality of cardiovascular disease.
S. Almeida, M. Budoff
semanticscholar   +1 more source

Platelet membrane-coated nanoparticle-mediated targeting delivery of Rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein E-deficient (ApoE-/-) mice.

Nanomedicine : nanotechnology, biology, and medicine, 2019
Although certain success has been achieved in atherosclerosis treatment, tremendous challenges remain in developing more efficient strategies to treat atherosclerosis.
Yanan Song, Zheyong Huang, Xin Liu, Z. Pang, Jing Chen, Hongbo Yang, Ning Zhang, Zhonglian Cao, Ming Liu, Jiatian Cao, Chenguang Li, Xiangdong Yang, H. Gong, J. Qian, J. Ge   +14 more
semanticscholar   +1 more source

Noninvasive Coronary Atherosclerotic Plaque Imaging

JACC: Cardiovascular Imaging, 2023
Coronary artery disease is the leading cause of morbidity and mortality worldwide. Despite remarkable advances in the management of coronary artery disease, the prediction of adverse coronary events remains challenging. Over the preceding decades, considerable effort has been made to improve risk stratification using noninvasive imaging.
Jacek Kwiecinski, Evangelos Tzolos, Michelle C. Williams, Damini Dey, Daniel Berman, Piotr Slomka, David E. Newby, Marc R. Dweck   +7 more
openaire   +2 more sources

Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques.

Journal of the American Chemical Society, 2023
Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine cathepsin.
Yuan Ma, Jinhui Shang, Liuhui Liu, Menghuan Li, Xinyu Xu, Hui Cao, Li Xu, Wei Sun, Guosheng Song, Xiao-Bing Zhang   +9 more
semanticscholar   +1 more source

Rapid inhibition of atherosclerotic plaque progression by sonodynamic therapy

Cardiovascular Research, 2018
Aims Currently, efficient regimens to reverse atherosclerotic plaques are not available in the clinic. Herein, we present sonodynamic therapy (SDT) as a novel methodology to rapidly inhibit progression of atherosclerotic plaques. Methods and results In
Xin Sun, Shuyuan Guo, Jianting Yao, Huan Wang, Cheng-hai Peng, Bicheng Li, Yu Wang, Yongxing Jiang, Tengyu Wang, Yang Yang, Jiali Cheng, Wei Wang, Zhengyu Cao, Xuezhu Zhao, Xiang Li, Jing Sun, Jiemei Yang, Fang Tian, Xi Chen, Qiannan Li, Weiwei Gao, Jing Shen, Qi Zhou, Peng Wang, Zhitao Li, Z. Tian, Zhiguo Zhang, W. Cao, Min Li, Ye Tian   +29 more
semanticscholar   +1 more source

Development of atherosclerotic plaques

Acta Medica Scandinavica, 1985
ABSTRACT. Atherosclerosis is a multifactorial disease. A unified model for the lesion development reveals many connections between the response‐to‐injury hypothesis and the lipid hypothesis. Various cellular uptake mechanisms for native and modified lipoproteins are discussed with respect to foam cell formation and lesion development.
openaire   +2 more sources