Results 161 to 170 of about 1,082,648 (349)
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
A White Oak Plaque of the Flying Cloud made by a Steamship Officer [PDF]
, 1929 openalex +1 more source
Secukinumab in plaque psoriasis--results of two phase 3 trials.
New England Journal of Medicine, 2014 R. Langley +19 more
semanticscholar +1 more source
Advanced Science, EarlyView.Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu +12 more
wiley +1 more source
Advanced Science, EarlyView.Migrasomes play a crucial role in endothelial‐immune interactions in atherosclerosis. This study identifies migrasomes as amplifiers in the inflammatory cascade, driving immune‐metabolic reprogramming via “migrasome‐APP‐CD74” signaling. Blocking CD74 disrupts migrasome‐mediated signaling, attenuating atherosclerosis progression.
Kangnan Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang +9 more
wiley +1 more source
Preparation and evaluation of fiber metal nickel battery plaques third quarterly progress report, feb. 1 - apr. 30, 1965 [PDF]
Effect of fiber size opon internal surface area and pore size of nickel fiber metal ...
Bidler, J. L., Fisher, J. I.
core +1 more source