Results 201 to 210 of about 1,146,198 (394)
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Nature Medicine, 2017 Zhuohao He, Jing L Guo, Jennifer D. McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J. Gathagan, C. Yue, C. Dengler, Anna M. Stieber, Magdalena Nitla, D. Coulter, T. Abel, K. Brunden, J. Trojanowski, V. Lee +16 moresemanticscholar +1 more sourceA dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9
Advanced Science, EarlyView.This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou +12 morewiley +1 more sourceThe Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang +36 morewiley +1 more sourceIntertidal Warfare: Synergistic Allelopathy Mediates Spatial Competition between Two Marine Calcareous‐Shelled Sessile Organisms
Advanced Science, EarlyView.This study reveals a hidden chemical weapon among calcareous‐shelled sessile organisms in the intertidal zone: the barnacle Balanus albicostatus releases a synergistic blend of palmitic acid and 1‐palmitoyl‐sn‐glycero‐3‐phosphocholine as the allelochemical with the inhibitory activity against attachment of the mussel Vignadula atrata, which may mediate Zhuo Li, Zixin Huo, Shanshan Yao, Xianmeng Liang, Yiran Zhao, Yanxin Wang, Shifeng Guo, Caihuan Ke, Pei Su, Danqing Feng +9 morewiley +1 more sourceAngioscopic Evaluation of Stabilizing Effects of Bezafibrate on Coronary Plaques in Patients With Coronary Artery Disease
, 2000 Yasumi Uchida, Yoshiharu Fujimori, Hidefumi Ohsawa, Jyunichi Hirose, Hirofumi Noike, Keiichi Tokuhiro, Masahito Kanai, Masaki Yoshinuma, Kazuhito Mineoka, Takashi Hitsumoto, Kaneyuki Aoyagi, Takeshi Sakurai, Shin Sato, Kokushi Yoshinaga, Masaaki Ozegawa, Hiroshi Morio, Katsumi Yamada, Kimiko Terasawa, Yuuko Uchida, Tomomitsu Oshima +19 moreopenalex +1 more sourceContribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury
Advanced Science, EarlyView.Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu +11 morewiley +1 more source