Results 341 to 350 of about 1,105,082 (410)

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

open access: yesBioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay   +9 more
wiley   +1 more source

Memory Gate Controlled by Contexts: Potential Key Structure That Could Link Small Associative Failures With Severe Cognitive Disorders

open access: yesBioEssays, EarlyView.
Memory gate (MG) hypothesis assumes a neural structure that connects inputs to appropriate contexts. Panel A shows an input (green) that, in the MG, does not match the context (red): memory does not recognize it. Panel B shows that, in the MG, the context (green) matches the input: memory recognizes the pattern.
Eduardo Mizraji, Juan Lin, Andrés Pomi
wiley   +1 more source

Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases

open access: yesBioEssays, EarlyView.
The energy landscape of Aβ reveals its flexible, “chameleon‐like” behavior, enabling diverse structures from disordered to β‐rich forms. This polymorphism facilitates aggregation, contributing to Alzheimer's disease progression, while the flat landscape also allows disaggregation, potentially slowing disease progression compared to prion proteins with ...
Birgit Strodel
wiley   +1 more source

Restoration of human tooth enamel

open access: yesBMEMat, EarlyView.
Human tooth enamel has remarkable properties but lacks self‐repair ability. Existing restorative materials cannot fully replicate enamel's microstructure and function, resulting in low restorative efficiency. This review summarizes the formation process and characteristics of enamel, and current restorative materials and future research directions are ...
Hanlin Liu   +10 more
wiley   +1 more source

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