Results 111 to 120 of about 29,718 (289)

Vaccine-induced skewing of T cell responses protects against Chikungunya virus disease [PDF]

, 2019
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T ...
Ando, Takeshi, Broeckel, Rebecca M, Curiel, David T, DeFilippis, Victor, Denton, Michael, Dmitriev, Igor, Haese, Nicole, Heise, Mark, Kreklywich, Craig N, Messaoudi, Ilhem, Morrison, Thomas E, Powers, John, Smith, Patricia, Streblow, Daniel N   +13 more
core   +3 more sources

An epidemiological survey of the current status of Zika and the immune interaction between dengue and Zika infection in Southern Taiwan

International Journal of Infectious Diseases, 2020
Objectives: This study was performed to examine the current status of Zika and the effects of pre-existing dengue immunity on Zika virus (ZIKV) infection in Southern Taiwan. Methods: A phylogenetic tree was used to analyze the phylogeny of detected ZIKVs.
Wen-Hung Wang, Aspiro Nayim Urbina, Chia-Ching Wu, Chih-Yen Lin, Arunee Thitithanyanont, Wanchai Assavalapsakul, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang   +8 more
doaj   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Clinical efficacy, safety, and immunogenicity of a live attenuated tetravalent dengue vaccine (CYD-TDV) in Children: a systematic review with meta-analysis [PDF]

, 2017
BACKGROUND Dengue hemorrhagic fever is the leading cause of hospitalization and death in children living in Asia and Latin America. There is an urgent need for an effective and safe dengue vaccine to reduce morbidity and mortality in this high-risk ...
Amar-Singh, Amarasinghe, Bhatt, Bonita, Borenstein, Bouckenooghe, Brady, Capeding, Capeding, Crevat, Crevat, da Costa, Dayan, Endy, Faheem, Guy, Halstead, Haven, Hesse, Higgins, Higgins, Hombach, Huedo-Medina, Kurane, Lam, Lanata, Leo, Long, L’Azou, Malavige, Moher, Moi, Morrison, Murrell, Mustafa, Poo, Rainwater-Lovett, Ramakrishnan, Riedmann, Sabchareon, Sabchareon, Screaton, Tan, Tang, Thomas, Thomas, Timiryasova, Tran, Villar, Villar, Wahala, Yacoub, Yauch   +52 more
core   +3 more sources

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]

, 2019
Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet, Manchala, Nageswar Reddy, Pilankatta, Rajendra, Trivedi, Pankaj, Unniyampurath, Unnikrishnan   +4 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Zika virus infection in pregnant women in Honduras: study protocol [PDF]

, 2016
Background: Although there is increasing evidence for a relationship between symptomatic Zika virus (ZIKV) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies.
Amanda M. Berrueta, Carolina Bustillo, Concepcion Zuniga, Dawn M. Wesson, Eduardo Bergel, Emily Harville, Fernando Althabe, Jackeline Alger, Karla Rosales, Maria-Luisa Cafferata, null null, Pierre Buekens   +11 more
core   +1 more source