Results 81 to 90 of about 29,718 (289)

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

Advanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao, Darine D'Adam, Anna Hu, Sixuan Zhang, Josua Roduner, Katharina Maniura‐Weber, Qun Ren   +6 more
wiley   +1 more source

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models. [PDF]

, 2018
Zika virus (ZIKV) infection during the large epidemics in the Americas is related to congenital abnormities or fetal demise. To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection.
Hu, Q, Ke, X, Li, P, Liu, Y, Luo, D, Miao, Y, Sun, J, Tan, Z, Wang, H, Wang, T, Xu, F, Zhang, Y, Zheng, Z   +12 more
core   +1 more source

Evaluation of three alternative methods to the plaque reduction neutralizing assay for measuring neutralizing antibodies to dengue virus serotype 2

Virology Journal
Background Dengue is a global public health challenge which requires accurate diagnostic methods for surveillance and control. The gold standard for detecting dengue neutralizing antibodies (nAbs) is the plaque reduction neutralization test (PRNT), which
Vanessa Shi Li Goh, Christopher Chong Wei Ang, Swee Ling Low, Pei Xuan Lee, Yin Xiang Setoh, Judith Chui Ching Wong   +5 more
doaj   +1 more source

Diagnosis of arboviruses using indirect sandwich IgG ELISA in horses from the Brazilian Amazon

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Background The Amazon as a whole is the largest reservoir of arboviruses worldwide, while the Brazilian Amazon hosts the largest variety of arboviruses isolated to date.
Alexandre do Rosário Casseb, Márcio Roberto Teixeira Nunes, Sueli Guerreiro Rodrigues, Elizabeth Salbé Travassos da Rosa, Livia Medeiros Neves Casseb, Samir Manssor Moraes Casseb, Sandro Patroca da Silva, Érika Dayane Leal Rodrigues, Pedro Fernando da Costa Vasconcelos   +8 more
doaj   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages [PDF]

, 2019
open access articlePurpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon.
Capparelli, Rosanna, Capuano, Federico, Contaldi, Felice, Della Ventura, Bartolomeo, Fulgione, Andrea, Giannini, Cinzia, Ianniello, Flora, Lelli, Marco, Papaianni, Marina, Pastore, Stella, Roveri, Norberto, Sgamma, Tiziana, Velotta, Raffaele   +12 more
core   +2 more sources

Evaluation of Chimeric Japanese Encephalitis and Dengue Viruses for Use in Diagnostic Plaque Reduction Neutralization Tests [PDF]

Clinical and Vaccine Immunology, 2009
ABSTRACTThe plaque reduction neutralization test (PRNT) is a specific serological test used to identify and confirm arbovirus infection in diagnostic laboratories and monitor immunological protection in vaccine recipients. Wild-type (wt) viruses used in the PRNT may be difficult to grow and plaque titrate, such as the dengue viruses (DENV), and/or may ...
Barbara W, Johnson, Olga, Kosoy, Elizabeth, Hunsperger, Manuela, Beltran, Mark, Delorey, Farshad, Guirakhoo, Thomas, Monath   +6 more
openaire   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Development and evaluation of a novel high-throughput image-based fluorescent neutralization test for detection of Zika virus infection. [PDF]

PLoS Neglected Tropical Diseases, 2018
Zika virus (ZIKV) is an emerging arbovirus belonging to the genus flavivirus that comprises other important public health viruses, such as dengue (DENV) and yellow fever (YFV).
Andrea Cristine Koishi, Andréia Akemi Suzukawa, Camila Zanluca, Daria Elena Camacho, Guillermo Comach, Claudia Nunes Duarte Dos Santos   +5 more
doaj   +1 more source

Serological Evidence of Orthopoxvirus Infection in Neotropical Primates in Brazil

Pathogens, 2022
The genus Orthopoxvirus (OPXV) of the family Poxviridae comprises several viruses that are capable of infecting a wide range of hosts. One of the most widespread OPXVs is the Vaccinia virus (VACV), which circulates in zoonotic cycles in South America ...
Filipe Vieira Santos de Abreu, Kamila Lorene Soares Rocha, Ramon Silva-Oliveira, Mariana Viana Macedo, Thamires Gabriele Macedo Silva, Maria Eduarda Gonçalves-dos-Santos, Cirilo Henrique de Oliveira, Sandy Micaele Aquino-Teixeira, Vinícius de Oliveira Ottone, Alex Junio Jardim da Silva, Ronaldo Medeiros dos Santos, Aline Tátila-Ferreira, Marco Antônio Barreto de Almeida, Edmilson dos Santos, Jáder da Cruz Cardoso, Aline Alves Scarpellini Campos, George Rego Albuquerque, Anaiá da Paixão Sevá, Bergmann Morais Ribeiro, Danilo Simonini Teixeira, Fabrício Souza Campos, Ana Cláudia Franco, Paulo Michel Roehe, Giliane de Souza Trindade, Danilo Bretas de Oliveira   +24 more
doaj   +1 more source