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Genes potentially involved in plaque rupture
Current Opinion in Lipidology, 2002 Rupture of an atherosclerotic plaque is the predominant underlying event in the pathogenesis of acute coronary syndromes and stroke. While ruptured plaques are morphologically well described, the precise molecular mechanisms involved in plaque rupture are still incompletely understood.
Birgit C G, Faber +3 more
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Cardiovascular Research, 2021 Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture and erosion.Methods and results Intracoronary optical coherence tomography performed in 37 patients with acute coronary syndromes caused by plaque rupture (n=19) or ...
Vikas Thondapu +2 more
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HISTOPATHOLOGY OF PLAQUE RUPTURE
Cardiology Clinics, 1999Plaque disruption occurs during the development of atherosclerotic lesions. During certain circumstances it may result in thrombosis and subsequent development of acute coronary syndromes. Several characteristics of the plaque appear to be associated with plaque disruption, including a large lipid rich core, superficial plaque inflammation, and a thin ...
Ravn, Hanne Berg, Falk, Erling
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The Lancet, 2009
A 74-year-old man presented with left-sided monocular visual loss as a result of branch retinal artery occlusion. Carotid ultrasonography showed mild (20%) left carotid artery stenosis but no embolic source was identifi ed. MRI of the carotid artery showed a large atherosclerotic plaque at the origin of the left internal carotid artery, despite only ...
Niall G, Keenan +4 more
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A 74-year-old man presented with left-sided monocular visual loss as a result of branch retinal artery occlusion. Carotid ultrasonography showed mild (20%) left carotid artery stenosis but no embolic source was identifi ed. MRI of the carotid artery showed a large atherosclerotic plaque at the origin of the left internal carotid artery, despite only ...
Niall G, Keenan +4 more
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Echolucent rupture-prone plaques
Current Opinion in Lipidology, 2003Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rupture-prone plaques and risk for ischaemic events ...
Børge G, Nordestgaard +2 more
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Mouse models of plaque rupture
Current Opinion in Lipidology, 2013Atherosclerotic plaque destabilization and rupture is an important pathological condition that may account for approximately 70% of acute myocardial infarction cases. To analyse the mechanisms by which an atherosclerotic plaque destabilizes and ruptures and examine the effects of novel therapeutic approaches, several groups have developed mouse models ...
Tetsuya, Matoba +2 more
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PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION
Cardiology Clinics, 1996Atherosclerotic coronary artery disease is the major cause of death, in men and women, in the United States and in much of the Western world. Atherosclerosis is responsible for coronary heart disease, limb ischemia, and most strokes. Although luminal narrowing by an atherosclerotic plaque and exaggerated or anomalous vasoconstriction contribute to some
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2021
Despite improvement in the treatment, prevention, and risk factor management of atherosclerosis, the most frequent cause of death globally remains coronary artery disease. Therefore, it is essential to understand the underlying mechanisms involved in the manifestation of acute coronary syndromes, sudden cardiac death, or stable ischaemic heart disease.
Hiroyoshi Mori, Sho Torii, Renu Virmani
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Despite improvement in the treatment, prevention, and risk factor management of atherosclerosis, the most frequent cause of death globally remains coronary artery disease. Therefore, it is essential to understand the underlying mechanisms involved in the manifestation of acute coronary syndromes, sudden cardiac death, or stable ischaemic heart disease.
Hiroyoshi Mori, Sho Torii, Renu Virmani
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2007
It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development.
Takeshi, Sasaki +2 more
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It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development.
Takeshi, Sasaki +2 more
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Endothelial dysfunction in plaque rupture and plaque erosion
Heart and VesselsVascular endothelial function plays an important role in the pathophysiology of acute coronary syndrome (ACS). Plaque erosion (PE) and plaque rupture (PR) are the two major mechanisms of ACS; however, how the vascular endothelial function differs between these etiologies is not well understood.
Yuki Ishii +10 more
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