Results 161 to 170 of about 47,117 (196)
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Drug Discovery Today: Disease Models, 2007
The most common underlying cause of the acute coronary syndromes is atherosclerotic plaque rupture, which is therefore of major clinical and pathological importance. Further insight into the aetiology of plaque rupture is essential to the development of new therapeutic strategies.
Christopher L. Jackson +3 more
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The most common underlying cause of the acute coronary syndromes is atherosclerotic plaque rupture, which is therefore of major clinical and pathological importance. Further insight into the aetiology of plaque rupture is essential to the development of new therapeutic strategies.
Christopher L. Jackson +3 more
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Proteinases and plaque rupture
Current Opinion in Lipidology, 2014To review progress over the past 5 years in relating extracellular proteinases to plaque rupture, the cause of most myocardial infarctions, and consider the most promising prospects for developing related treatments.Cysteinyl cathepsins have been implicated in multiple macrophage functions that could promote plaque rupture. Cathepsin K is an attractive
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Numerical Simulation of Arterial Plaque Ruptures
International Journal of Material Forming, 2008We present three-dimensional finite element simulations of damaged arteries, used to investigate the influence of the geometry and tissue properties on the plaque rupture. We adopt a baseline geometry reconstructed from a contiguous set of in vitro magnetic resonance images of a damaged artery.
FERRARA, ANNA, PANDOLFI, ANNA MARINA
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Local and Systemic Mechanisms of Plaque Rupture
Angiology, 2008Mechanisms at the basis of coronary plaque instability are still elusive. On the one hand, accumulating data, from clinical and postmortem studies, suggest the role of systemic factors, in particular inflammation, in plaque rupture. On the other hand, local factors, in particular plaque composition, such as a large lipid-rich core and a thin fibrous ...
Luigi M, Biasucci +2 more
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PATHOPHYSIOLOGY AND INFLAMMATORY ASPECTS OF PLAQUE RUPTURE
Cardiology Clinics, 1996Atherosclerotic plaque disruption with superimposed thrombosis is the main cause of acute coronary events. At present it is not known specifically how various risk factors influence the development and configuration of coronary plaques. The risk of plaque disruption depends more on plaque composition and vulnerability (plaque type) than on the degree ...
A P, Schroeder, E, Falk
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Plaque Rupture, Thrombosis, and Therapeutic Implications
Pathophysiology of Haemostasis and Thrombosis, 1996The basic mechanisms of atherosclerotic progression leading to the acute coronary syndromes (ACS) have been elucidated during the few years. In this brief presentation, we outline 1) Definition of Atherosclerotic Lesions: eight morphologically different lesions are defined (Type I to VI) in various phases of disease.
V, Fuster +3 more
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Atherosclerosis and plaque rupture
Catheterization and Cardiovascular Interventions, 2001F G, Welt, D I, Simon
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2002
Background and Pathophysiology Development of the Atherosclerotic Plaque Joan W. Berman, Marwan Kazimi, and Harry Ma Clinical and Pathological Correlates Renu Virmani, Allen P. Burke, Andrew Farb, and Frank D. Kolodgie The Role of Inflammation in Plaque Rupture Anton E. Becker and Allard C.
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Background and Pathophysiology Development of the Atherosclerotic Plaque Joan W. Berman, Marwan Kazimi, and Harry Ma Clinical and Pathological Correlates Renu Virmani, Allen P. Burke, Andrew Farb, and Frank D. Kolodgie The Role of Inflammation in Plaque Rupture Anton E. Becker and Allard C.
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