Results 51 to 60 of about 374,414 (247)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Effect of shear stress on plaque rupture [PDF]

Canadian Journal of Cardiology, 2007
Apreviously asymptomatic 40-year-old woman was admitted to the emergency department with acute onset of left-sided chest pain on exertion. The initial electrocardiogram showed ST-segment elevation in the anterior leads, suggesting an anterior ST-segment elevation myocardial infarction. Symptoms improved after treatment with oxygen, acetylsalicylic acid
Pablo, Garcia-Pavia, Pablo, Aguiar-Souto, Raymundo, Ocaranza   +2 more
openaire   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Rupture du long fléchisseur du pouce : complication rare de l´ostéosynthèse par plaque anatomique palmaire du radius distal

PAMJ Clinical Medicine, 2020
La rupture du long fléchisseur du pouce secondaire à une ostéosynthèse par plaque palmaire est très rare. Elle est généralement due à la proéminence et/ou la position distale de la plaque. Son diagnostic est facile.
Thierno Souleymane Bah, Dondo Mara, Anass Abaydi, Ibrahim Marzouki, Mustapha Maâroufi, Boutayeb Fawzi   +5 more
doaj   +1 more source

The Spatial Distribution of Plaque Vulnerabilities in Patients with Acute Myocardial Infarction. [PDF]

PLoS ONE, 2016
OBJECTIVE:Although the plaque characteristics have been recognized in patients with acute myocardial infarction (AMI), the plaque spatial distribution is not well clarified.
Guian Zheng, Yuxin Li, Tadateru Takayama, Toshihiko Nishida, Mitsumasa Sudo, Hironori Haruta, Daisuke Fukamachi, Kimie Okubo, Yoshiharu Higuchi, Takafumi Hiro, Satoshi Saito, Atsushi Hirayama   +11 more
doaj   +1 more source

Myocardial Bridge and Acute Plaque Rupture [PDF]

Journal of Investigative Medicine High Impact Case Reports, 2016
A myocardial bridge (MB) is a common anatomic variant, most frequently located in the left anterior descending coronary artery, where a portion of the coronary artery is covered by myocardium. Importantly, MBs are known to result in a proximal atherosclerotic lesion.
Leor Perl MD, David Daniels MD, Jonathan Schwartz MD, Shige Tanaka MD, PhD, Alan Yeung MD, Jennifer A. Tremmel MD, Ingela Schnittger MD   +6 more
openaire   +3 more sources

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Is cadmium exposure associated with the burden, vulnerability and rupture of human atherosclerotic plaques?

PLoS ONE, 2015
The general population is exposed to cadmium from food and smoking. Cadmium is a widely spread toxic pollutant that seems to be associated with cardiovascular diseases, although little is known if it contributes to the occurrence of atherosclerotic ...
Göran Bergström, Björn Fagerberg, Gerd Sallsten, Thomas Lundh, Lars Barregard   +4 more
doaj   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Atherosclerotic plaque features relevant to rupture-risk detected by clinical photon-counting CT ex vivo: a proof-of-concept study

European Radiology Experimental
Background To identify subjects with rupture-prone atherosclerotic plaques before thrombotic events occur is an unmet clinical need. Thus, this proof-of-concept study aims to determine which rupture-prone plaque features can be detected using clinically ...
Annelie Shami, Jiangming Sun, Chrysostomi Gialeli, Hanna Markstad, Andreas Edsfeldt, Marie-Louise Aurumskjöld, Isabel Gonçalves   +6 more
doaj   +1 more source