Results 31 to 40 of about 42,323 (259)

Combined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis

Artery Research, 2010
Background: Rupture of carotid plaques is an important cause of cerebrovascular events. Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerability.
Giulia Soloperto, Niall G. Keenan, Mary N. Sheppard, Jacques Ohayon, Nigel B. Wood, Dudley J. Pennell, Raad H. Mohiaddin, Xiao Yun Xu   +7 more
doaj   +1 more source

Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

JACC: Basic to Translational Science, 2020
Summary: During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction ...
Jianting Yao, MD, PhD, Weiwei Gao, MD, Yu Wang, MD, PhD, Lu Wang, PhD, Kamal Diabakte, MD, Jinyang Li, MD, Jiemei Yang, MD, Yongxing Jiang, MD, Yuerong Liu, MD, Shuyuan Guo, MD, Xuezhu Zhao, MD, Zhengyu Cao, MD, Xi Chen, MD, PhD, Qiannan Li, MD, Haiyu Zhang, PhD, Wei Wang, MD, Zhen Tian, PhD, Bicheng Li, MD, PhD, Fang Tian, MD, PhD, Guodong Wu, MD, Shirin Pourteymour, PhD, Xi Huang, MD, Fancheng Tan, MD, Xiaoru Cao, MD, Zhuowen Yang, MD, Kang Li, PhD, Yan Zhang, PhD, Yong Li, MD, PhD, Zhiguo Zhang, PhD, Hong Jin, MD, PhD, Ye Tian, MD, PhD   +30 more
doaj   +1 more source

Prevalence of Healed Plaque and Factors Influencing Its Characteristics Under Optical Coherence Tomography in Patients With Coronary Artery Disease: A Systematic Review, Meta-Analysis, and Meta-Regression

Frontiers in Cardiovascular Medicine, 2021
Aim: The purpose of this study was to determine the prevalence of healed plaque and its characteristics under optical coherence tomography (OCT) through a formal systematic review, meta-analysis, and meta-regression.Methods and Results: Thirteen studies ...
Xunxun Feng, Yang Liu, Jiaqi Yang, Guangyao Zhai, Yujie Zhou, Qianyun Guo   +5 more
doaj   +1 more source

Differences between the Molecular Mechanisms Underlying Ruptured and Non-Ruptured Carotid Plaques, and the Significance of ABCA1 [PDF]

Journal of Stroke, 2018
Background and Purpose Carotid plaques are a strong risk factor for ischemic stroke, and plaque rupture poses an even higher risk. Although many studies have investigated the pathogenic mechanisms of carotid plaque formation, few have studied the ...
Sung Hyuk Heo, Eun-Hye Lee, Hyun-Hee Park, Bum Joon Kim, Hyo Chul Youn, Young Seo Kim, Hyun Young Kim, Seong-Ho Koh, Dae-Il Chang   +8 more
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Coronary Atherosclerosis Imaging

Diagnostics, 2020
Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention.
Michael Y. Henein, Sergio Vancheri, Gani Bajraktari, Federico Vancheri   +3 more
doaj   +1 more source

Coronary Plaque Characteristics and Underlying Mechanism of Acute Coronary Syndromes in Different Age Groups of Patients With Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background High cardiovascular mortality has been reported in young patients with diabetes. However, the underlying pathology in different age groups of patients with diabetes has not been studied.
Keishi Suzuki, Takayuki Niida, Haruhito Yuki, Daisuke Kinoshita, Daichi Fujimoto, Hang Lee, Iris McNulty, Masamichi Takano, Sunao Nakamura, Tsunekazu Kakuta, Kyoichi Mizuno, Ik‐Kyung Jang   +11 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Putative Murine Models of Plaque Rupture [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
To be useful, animal models for human diseases must be well defined.1 Thus we are concerned that investigators will be mislead by the definitions and terminology used by Jackson et al1a to describe putative plaque rupture models in mice. We are especially concerned with their use of “acute plaque rupture” to describe murine lesions that do not mimic ...
Falk, Erling, Schwartz, Stephen M, Galis, Zorina S, Rosenfeld, Michael E   +3 more
openaire   +1 more source