Results 191 to 200 of about 160,587 (337)

Essential hyperbolicity and homoclinic bifurcations: a dichotomy phenomenon/mechanism for diffeomorphisms

open access: yes, 2010
We prove that any diffeomorphism of a compact manifold can be approximated in topology C1 by another diffeomorphism exhibiting a homoclinic bifurcation (a homoclinic tangency or a heterodimensional cycle) or by one which is essentially hyperbolic (it has
Crovisier, Sylvain, Pujals, Enrique R.
core   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment. [PDF]

open access: yesFront Cardiovasc Med
Chen Y   +11 more
europepmc   +1 more source

Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis. [PDF]

open access: yesNutrients, 2022
Ambreen S   +13 more
europepmc   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

open access: yesAdvanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang   +27 more
wiley   +1 more source

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