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Plaque Stability and Carotid Stenting [PDF]
, 2009 Carotid angioplasty and stenting (CAS) is increasingly being performed for the treatment of severely stenotic carotid disease [1–5]. Despite, this growing acceptance, the recently published data of the Eva-3S trial [6], performed in France, and the SPACE trial [7] in Germany failed to prove superiority of CAS over CEA.
Koen Deloose +2 more
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Plaque stabilization: the role of lipid lowering [PDF]
International Journal of Cardiology, 2000 The unstable atheroma characteristically has a thin, eccentric fibrous cap and a large necrotic core of lipid and cellular debris. This plaque configuration is particularly unstable because large mechanical stresses develop in the thinnest portions of the fibrosis cap over the lipid pool.
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Update in Therapeutic Approaches to Plaque Stabilization
Current Atherosclerosis Reports, 2014Increasing pathological insights have highlighted the role of plaque instability in the pathogenesis of acute ischemic syndromes. These studies have identified a specific plaque phenotype, characterized by large burden, expansive arterial wall remodeling, and greater composition of lipid, inflammatory, and necrotic material, as the disease most likely ...
Yu Kataoka, Stephen J. Nicholls
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Archives of Biochemistry and Biophysics, 2020
Our previous research revealed that trypsin is abundantly expressed in atherosclerotic plaques and its distribution overlaps with that of matrix metalloproteinase-9 (MMP-9). This study was performed to explore the possible roles of trypsin in vulnerable atherosclerotic plaque formation.Twenty-four rabbits were randomly assigned to a normal (control ...
Min Pan +4 more
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Our previous research revealed that trypsin is abundantly expressed in atherosclerotic plaques and its distribution overlaps with that of matrix metalloproteinase-9 (MMP-9). This study was performed to explore the possible roles of trypsin in vulnerable atherosclerotic plaque formation.Twenty-four rabbits were randomly assigned to a normal (control ...
Min Pan +4 more
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Plaque stabilizing effects of apolipoprotein A-IV
Atherosclerosis, 2016Apolipoprotein (apo) A-IV, the third most abundant HDL-associated protein, is atheroprotective and shares similar properties as apoA-I. We have reported previously that apoA-I, the most abundant apolipoprotein in HDL, inhibits plaque disruption in a mouse model. We aimed at examining the effects of apoA-IV on markers of plaque stability in vivo.Plaques
Kate Shearston +6 more
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Can we stabilize unstable plaque?
Current Atherosclerosis Reports, 2003From these considerations, successful therapeutic approaches should control multiple aspects of plaque stabilization. Statins fulfill such a requirement, yet combination therapy may be of use in specific clinical settings. Despite remarkable therapeutic achievements in the management of acute coronary syndromes, mortality rates for this disease ...
PAOLETTI R, CIGNARELLA, ANDREA
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Carotid Atherosclerotic Plaques Stabilize After Stroke
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009Objective— Rupture of unstable atherosclerotic plaques is the pathological substrate for acute ischemic events. Underlying cellular and molecular characteristics of plaque rupture have been studied extensively.
Gerard Pasterkamp +6 more
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Regression and stabilization of atherogenic plaques
Trends in Cardiovascular MedicineAtherosclerotic plaque assessment has become a crucial element in the examination of cardiovascular diseases. Plaque may exhibit progression and could become unstable if not treated, making plaque regression and stabilization among the most important goals of any cardiovascular intervention in cardiovascular medicine.
Jairo Aldana-Bitar +2 more
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Cardiovascular Pathology, 2009
Fibrates are peroxisome proliferator-activated receptor alpha (PPARalpha) agonists which modulate many aspects of lipoprotein metabolism and inflammation. They have been recently demonstrated to inhibit in vitro expression of tissue factor (TF), the main initiator of blood coagulation, which probably plays a pivotal role in thrombotic complications ...
Brigitte Jude +11 more
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Fibrates are peroxisome proliferator-activated receptor alpha (PPARalpha) agonists which modulate many aspects of lipoprotein metabolism and inflammation. They have been recently demonstrated to inhibit in vitro expression of tissue factor (TF), the main initiator of blood coagulation, which probably plays a pivotal role in thrombotic complications ...
Brigitte Jude +11 more
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Stabilization of atherosclerotic plaque during lipid lowering
Current Opinion in Lipidology, 1997Lipid lowering therapy leads to a great reduction of cardiovascular complications, but has almost no effect on the degree of stenosis of coronary arteries. These findings have lead to a new paradigm of coronary artery disease, i.e. clinical prognosis is not only determined by the extent of a single stenosis, but mainly by the number and structure of ...
Dirk Müller-Wieland +2 more
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