Results 131 to 140 of about 5,828,869 (328)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effects of Plasma and Activated Water on Biological Characteristics of Bromus inermis Seeds Under Different Power Supply Excitation

Plasma
To explore the potential of plasma technology in regulating seed germination, this study compared the effects of direct treatment with needle-plate electrodes using DC and pulse power supplies, and indirect treatment with plasma-activated water on the ...
Jiawen Xie, Fubao Jin, Shangang Ma, Jinqiang Shi, Yanming Qi   +4 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

PIC Modeling of Ionospheric Plasma Diagnostics by Hemispherical Probes: Study of the LAP-CSES at Magnetic Conjugates

Plasma
We present three dimensional particle-in-cell simulations of current-voltage characteristics of the hemispherical Langmuir probe (LAP), onboard the China Seismo-Electromagnetic Satellite (CSES).
Nadia Imtiaz, Saeed Ur Rehman, Liu Chao, Rui Yan, Richard Marchand   +4 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Modeling Streamer Discharge in Air Using Implicit and Explicit Finite Difference Methods with Flux Correction

Plasma
Implementing a computationally efficient numerical model for a single streamer discharge is essential to understand the complex processes such as lightning initiation and electrical discharges in high voltage systems. In this paper, we present a streamer
Hasupama Jayasinghe, Liliana Arevalo, Richard Morrow, Vernon Cooray   +3 more
doaj   +1 more source

Reference Intervals for Plasma L-Arginine and the L-Arginine:Asymmetric Dimethylarginine Ratio in the Framingham Offspring Cohort [PDF]

, 2011
Nicole Lüneburg, Vanessa Xanthakis, Edzard Schwedhelm, Lisa Sullivan, Renke Maas, Maike Anderssohn, Ulrich Riederer, Nicole L. Glazer, Ramachandran S. Vasan, Rainer H. Böger   +9 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Inactivation of Bioaerosol Particles in a Single-Pass Multi-Stage Non-Thermal Plasma and Ionization Air Cleaner

Plasma
Bioaerosol particles contribute to the reduced indoor air quality and cause various health issues, thus their concentration must be managed. Air cleaning is one of the most viable technological options for reducing quantities of indoor air contaminants ...
Justinas Masionis, Darius Čiužas, Edvinas Krugly, Martynas Tichonovas, Tadas Prasauskas, Dainius Martuzevičius   +5 more
doaj   +1 more source

Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies [PDF]

, 2018
Eva Germovsek, Irja Lutsar, Karin Kipper, Mats O. Karlsson, Tim Planche, Corine Chazallon, Laurence Meyer, Ursula Trafojer, Tuuli Metsvaht, Isabelle Fournier, Mike Sharland, Paul T. Heath, Joseph F. Standing, Cinzia Auriti, Susanna Esposito, Pugini Lorenza, Mari‐Liis Ilmoja, Nijolė Drazdienė, Kosmas Sarafidis, Georgıos Mitsiakos, Michiel van der Flier, Paul Clarke, Andrew Collinson, Samir Gupta, Mark Anthony, Mark Thomas, Santosh Pattnayak, Jonathan Davis, Heike Rabe, Elizabeth A. Pilling, Srini Bandi, Ajay Sinha   +31 more
openalex   +1 more source