Results 171 to 180 of about 85,932 (298)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Numerical study of self-injected electron acceleration in CNT structured targets driven by an 800 nm laser. [PDF]

Sci Rep
Bonţoiu C, Bonatto A, Apsimon Ö, Bandiera L, Cavoto G, Drebot I, Gatti G, Giner-Navarro J, Lei B, Martín-Luna P, Rago I, Rodríguez Pérez J, Nunes BS, Sytov A, Valagiannopoulos C, Welsch CP, Xia G, Zhang J, Resta-López J.   +18 more
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods. [PDF]

Front Med (Lausanne)
Zheng G, Yang X, Chen Y, Zhang P, Nie Q.
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Proteomic profiling and pathway analyses reveal molecular signatures and immune networks in pediatric sepsis. [PDF]

Inflamm Res
Stranges V, Van Nynatten LR, Tweddell D, Cela E, Morello M, Daley M, O'Gorman DB, Cepinskas G, Fraser DD.   +8 more
europepmc   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Proteomic profiling of spontaneous myopia in guinea pigs. [PDF]

Front Med (Lausanne)
Liu H, Zhou Y, Li X, Sun H, Hsiao Y, Wen L, Xu Q, Chen Z, Lan W, Yang Z.   +9 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan. [PDF]

Aging Cell
Bene MR, Zhang C, Westbrook R, Gabrawy M, Marx R, Wu Y, Khadeer M, Ubaida-Mohien C, Ferrucci L, Moaddel R, Le A, Walston JD, Lee JL, Abadir PM.   +13 more
europepmc   +1 more source