Results 181 to 190 of about 85,932 (298)

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Single-cell landscape of piglet lung response with <i>Actinobacillus pleuropneumoniae</i>. [PDF]

Virulence
Zhu J, Zhu S, Xia C, Jiang X, Bao C, Li Z, Zhu R, Jiang H, Li F, Zhang X, Wang W, Chen H, Mei J, Gu J, Li N, Lei L.   +15 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Single-event fast neutron time-of-flight spectrometry with a petawatt-laser-driven neutron source. [PDF]

Nat Commun
Millán-Callado MA, Scheuren S, Alejo A, Benlliure J, Beyer R, Cowan TE, Fernández B, Griesmayer E, Junghans AR, Kohl J, Kroll F, Metzkes-Ng J, Prencipe I, Quesada JM, Rehwald M, Rödel C, Rodríguez-González T, Schramm U, Roth M, Štefaníková R, Urlass S, Weiss C, Zeil K, Ziegler T, Guerrero C.   +24 more
europepmc   +1 more source

Fe2+‐ Induced Activation of Single and Dual Metal Site—Lattice Oxygen Mechanism in Fe Rich NiFe‐LDHs for Oxygen Evolution Reaction

Advanced Science, EarlyView.
Fe‐rich NiFe‐LDH catalysts derived from MOFs, showing superior OER activity via lattice oxygen mechanism activation. ABSTRACT Developing a durable and efficient oxygen evolution reaction (OER) catalyst without noble metals is essential for the economical and sustainable production of hydrogen by alkaline water electrolysis.
Nithinraj Panangattu Dharmarajan, Mohammed Fawaz, Vanshree Parey, Sudip Chakraborty, CI Sathish, Thi Thuy Kieu Tran, Xuan Minh Chau Ta, Siddulu Naidu Talapaneni, Zhixuan Li, Kavitha Ramadass, Antonio Tricoli, Jae‐Hun Yang, Ajayan Vinu   +12 more
wiley   +1 more source

A Bubble-Driven Drug Delivery System Enhances Oral Absorption and Antipyretic Efficacy of Poorly Water-Soluble Andrographolide. [PDF]

Int J Nanomedicine
Zhou J, Luo W, Zeng L, Xu S, Wu R, Lu J, Li Y, Xiong W.   +7 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges. [PDF]

Beilstein J Nanotechnol
Tarasenka N.
europepmc   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids. [PDF]

Beilstein J Nanotechnol
Molina-Prados S, Bulgakova NM, Bulgakov AV, Lancis J, Vega GM, Doñate-Buendia C.   +5 more
europepmc   +1 more source