Results 141 to 150 of about 2,393,121 (307)

Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation

Frontiers in Immunology
IntroductionHigh levels of extracellular adenosine, highly abundant in the tumor microenvironment, promote immune suppression mainly through the A2AR expressed by tumor-infiltrating immune cells.
Paola Tieppo, Hussein Shehade, Chiara Martinoli, Marjorie Mercier, David Carbonez, Nicolas Rosewick, Sophie Jung, Anais Vezzu, Boris Pirlot, Noemie Wald, Stephanie Ma, Lucas Chaible, Reece Marillier, Francesco Strozzi, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Joao Marchante, Margreet Brouwer, Erica Houthuys, Michael Deligny, Yvonne McGrath, Maura Rossetti   +22 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Cutaneous Marginal Zone Lymphoproliferation Arising from Circumorificial Plasmacytosis During Nivolumab Therapy for Urothelial Carcinoma

Dermato
Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 antibodies, have significantly improved outcomes in a variety of solid tumors, including urothelial carcinoma.
Thilo Gambichler, Heinz-Wolfram Bernd, Sera Weyer-Fahlbusch, Anke Lücke, Johann Lorenzen, Laura Susok   +5 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Recent Developments in Solar Energy Harvesting and Photocatalysis

International Journal of Photoenergy, 2012
Junwang Tang, Songyuan Dai, Jawwad A. Darr   +2 more
doaj   +1 more source

Chronic endometritis – diagnosing difficulties (review)

Клинический разбор в общей медицине
Background. The relevance of the problem is associated with the lack of a unified strategy for managing patients with repeated implantation failures during assisted reproductive technology procedures due to chronic endometritis.
Igor O. Borovikov, Lidiya A. Papoyan, Daria V. Revenko, Kirill E. Golubchenko, Daria V. Ilyina, Karina M. Syrko   +5 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Humoral rejection in heart transplantation in the current era

JHLT Open
Immune response to the human leukocyte antigens (HLA) of a donor heart, resulting in antibody-mediated rejection (AMR), remains one of the greatest challenges in current transplant medicine. Besides the risk of acute functional deterioration of the graft
Jared Sheridan, Simon Urschel
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source