Results 71 to 80 of about 1,429,702 (267)

Combination of Whole Body MRI and MY-RADS: A Promising Standardised Approach for Treatment Response Evaluation in Multiple Myeloma Patients [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Multiple Myeloma (MM) is a malignancy that impacts the bones, kidneys, and immune system. Whole-body Magnetic Resonance Imaging (MRI) is recognised as the most sensitive modality for bone marrow assessment, providing advantages such as ...
Dipu Bhuyan, Hrishikesh Choudhury, Baloy Jyoti Talukdar, Subhosree Dey, Sushant Agarwal, Aditi Das, Rishabh   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Report of two rare cases of plasma cell granuloma of the gingiva [PDF]

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Plasma cell granuloma is a rare benign, occasionally aggressive lesion with an unclear etiopathogenesis characterized by plasma cell infiltration. It occurs mainly in the lungs but can also affect the liver, kidneys, brain, and heart.
Hannah Gil de Farias Morais, Renata Roque Ribeiro, José Nazareno Moreira de Aguiar Júnior, Victor Diniz Borborema dos Santos, Hevio Freitas de Lucena, Roseana de Almeida Freitas   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Pericapillary plasma cells in plasma cell myeloma [PDF]

American Journal of Hematology, 2010
Barbara J, Bain, E Mary, Thompson
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

First 100 days outcomes of cryopreserved vs non-cryopreserved stem cells autologous bone marrow transplant in multiple myeloma - a single center experience

Khyber Medical University Journal
Objective: To compare the first 100 days' outcomes of autologous stem cell transplantation (Auto-BMT) using cryopreserved versus non-cryopreserved grafts in multiple myeloma (MM) patients.
Awais Siddiq, Mehreen Ali Khan, Jehanzeb Ur Rehman, Irsa Hidayat, , Qudratullah, Munazza Nabi Awan, Hammad Javed   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Plasma cell leukaemia

Porto Biomedical Journal, 2016
Plasma cell leukaemia (PCL) is a rare and aggressive disease. Diagnosis is made when there are >2000/#mL circulating plasma cells in peripheral blood or plasmacytosis >20% of total leukocyte count. We report a case of a 51-year old man with generalized bone pain and constitutional symptoms.
Braga, Carlos Galvão, Rodrigues, Ana Raquel, Alves, Marina, Portela, Catarina, Pinto, Luísa, Marques, Herlander   +5 more
openaire   +2 more sources