Results 81 to 90 of about 2,422,567 (286)

Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells [PDF]

, 2016
The asymmetric localization of proteins in the plasma membrane domains of eukaryotic cells is a fundamental manifestation of cell polarity that is central to multicellular organization and developmental patterning.
Friml, Jiri, Langowski, Lukasz, Li, Hongjiang, Naramoto, Satoshi, Tanaka, Hirokazu, Vanneste, Steffen, Wabnik, Krzysztof   +6 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Plasma cell clone immunophenotypic characteristics in patients with systemic AL-amyloidosis

Онкогематология
Immunophenotypic features of plasma cells (pC) in patients with systemic AL‑amyloidosis (AL‑A) are not fully characterized. The bone marrow of 113 patients with first diagnosed systemic AL‑A was studied by 10‑color flow cytofluorimetry.
N. A. Kashchavtseva, I. G. Rekhtina, I. V. Galtseva, N. M. Kapranov, K. A. Nikiforova, T. N. Obukhova, S. M. Kulikov, V. A. Surimova, L. P. Mendeleeva   +8 more
doaj   +1 more source

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection

, 2018
Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic.
Amara, Khaled, Baeten, Dominique, Gabay, Cem, Gronwall, Caroline, Israelsson, Lena, Klareskog, Lars, Lanzavecchia, Antonio, Lloyd, Katy A., Lundberg, Karin, Lundstrom, Susanna L., Malmstrom, Vivianne, Mueller, Daniel L., Piccoli, Luca, Reed, Evan, Steen, Johanna, Titcombe, Philip J., Zhou, Diana, Zubarev, Roman A.   +17 more
core   +2 more sources

Visualization of the exocyst complex dynamics at the plasma membrane of Arabidopsis thaliana [PDF]

, 2013
The exocyst complex, an effector of Rho and Rab GTPases, is believed to function as an exocytotic vesicle tether at the plasma membrane before soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation.
De Rycke, Riet, Drdová, Edita Janková, Fendrych, Matyáš, Nowack, Moritz, Pečenková, Tamara, Sekereš, Juraj, Synek, Lukáš, Žárský, Viktor   +7 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Zoon's balanitis treated with topical tacrolimus

Urology Annals, 2017
Zoon's balanitis is an asymptomatic lesion that requires histopathological examination of involved tissue for confirmation of diagnosis. Till today, circumcision is considered as the treatment of choice as topical medical therapy is insufficient to cure ...
Sudarshan O Daga, Vinayak G Wagaskar, Snehal F Jumnake, Sujata K Patwardhan   +3 more
doaj   +1 more source

Primary plasma cell leukaemia

British Journal of Haematology, 1994
Summary. Among 750 previously untreated patients with multiple myeloma, 27 (4%) presented with plasma cell leukaemia. All but one patient had high tumour mass and, when compared with comparable patients without leukaemia, more frequent extraosseous involvement, thrombocytopenia, high serum lactate dehydrogenase and hypodiploid plasma cells.
Dimopoulos MA, PALUMBO, Antonio, Delasalle KB, Alexanian R.   +3 more
openaire   +5 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source