Results 161 to 170 of about 1,851,789 (293)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain Concentrations Are Inversely Associated with Retinal Microvascular Perfusion and Vessel Density in Cognitively Normal Individuals with Familial or Genetic Risk Factors for Alzheimer's Disease. [PDF]

Diagnostics (Basel)
Zhao W, Zhu MY, Patel H, Whitson HE, Johnson KG, Grewal DS, Fekrat S.   +6 more
europepmc   +1 more source

A Single‐Solvent Acetone Strategy for Surface Enhancement and Robust Bonding in PMMA Microfluidic Devices

Advanced Materials Interfaces, EarlyView.
A single‐solvent acetone strategy simultaneously restores laser‐ablated PMMA surfaces and enables high‐strength bonding for microfluidic device fabrication. The process produces smooth, optically clear channels, achieves bonding strengths up to 27.3 MPa, and forms leak‐free devices within 25 min, providing a rapid and accessible route to robust PMMA ...
Sadık Koç, H. Cumhur Tekin
wiley   +1 more source

Modelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition. [PDF]

Brain
Cogswell PM, Lundt ES, Therneau TM, Hu M, Griswold ME, Wiste HJ, Machulda MM, Stricker NH, Braunstein JB, West T, Verghese PB, Graff-Radford J, Algeciras-Schimnich A, Lowe VJ, Schwarz CG, Senjem ML, Gunter JL, Knopman DS, Vemuri P, Petersen RC, Jack CR, Alzheimer’s Disease Neuroimaging Initiative.   +21 more
europepmc   +1 more source

Recent Advances in Plasma‐Enhanced Atomic Layer Etching for Next‐Generation Nanofabrication

Advanced Materials Interfaces, EarlyView.
Continued semiconductor miniaturization demands atomic‐scale patterning and ultralow surface roughness beyond the capabilities of conventional reactive ion etching. This review highlights advances in isotropic and anisotropic plasma‐enhanced atomic layer etching since 2020, covering fundamental mechanisms, applications across major semiconductor ...
Shih‐Nan Hsiao
wiley   +1 more source

Correlation of ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT Uptake Parameters with PASS and GAPP Scores in Pheochromocytoma. [PDF]

Diagnostics (Basel)
Ozturk Unsal I, Ucgul E, Unver CK, Dizdar N, Hepsen S, Calapkulu M, Erdem Karaoglu A, Cayir D, Cakal E.   +8 more
europepmc   +1 more source

Large‐Scale and Cost‐Effective Fabrication of Ultra‐Thin, Biodegradable Microelectrode Arrays and Pressure Sensors Using Laser Micromachining

Advanced Materials Technologies, EarlyView.
A mask‐free and cost‐effective UV‐pico‐second laser‐based microfabrication method is proposed to fabricate large‐area biodegradable microelectrode arrays and pressure sensors. These devices demonstrate low impedance, good conformability, excellent biocompatibility, and rapid degradation, providing a new route for next‐generation transient electronics ...
Bhavani Prasad Yalagala, Asfand Tanwear, María Cerezo‐Sánchez, Hossein Parvizi, Morteza Amjadi, Hadi Heidari   +5 more
wiley   +1 more source

Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers. [PDF]

Neurology
Shir D, Algeciras-Schimnich A, Piura YD, Bornhorst JA, Figdore DJ, Elgenidi A, Lachner C, Graff-Radford NR, Day GS.   +8 more
europepmc   +1 more source

Surrogate‐Optimized Flow‐Guided Miniature Condenser for Rapid Exhaled Glucose Detection

Advanced Materials Technologies, EarlyView.
A surrogate‐optimized miniature condenser guides humid exhaled flow toward cold surfaces to accelerate exhaled breath condensate collection. By improving vapor access within a compact footprint, the design increases sample yield. This enables post‐collection enrichment and rapid colorimetric glucose detection from dilute exhaled biomarkers within a 5 ...
Yiming Thomas Lu, Yamin Mansur, Sai Peri, Jiangyuan Wan, Amio Pronoy Das Ritwik, Emily L. Johnson, Jingcheng Ma   +6 more
wiley   +1 more source

Recent Advances in Transparent Microelectrode Device Architecture and Fabrication Strategies for Biomedical Applications

Advanced Materials Technologies, EarlyView.
Transparent microelectrode arrays enable simultaneous optical and electrical electrophysiology with high spatiotemporal resolution, allowing multimodal observations of dynamic biological systems. Advances in materials and device architectures improve device performance by addressing key trade‐offs between optical transparency, impedance, and ...
Michael Abraham Listyawan, Tran Bach Dang, Chi Cong Nguyen, Yee Lap Pong, Tianruo Guo, Thanh Nho Do, Hoang‐Phuong Phan   +6 more
wiley   +1 more source