Results 211 to 220 of about 1,851,789 (293)

Advancements in CRISPR/Cas Technologies for Sensitive Cancer Detection: Mechanisms, Platforms, and Clinical Translation Roadmap. [PDF]

Diagnostics (Basel)
Akter R, Ryu SW, Lee JH.
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Comparing Real-Time PCR and Amplicon-Based NGS for Routine <i>EGFR</i> Liquid Biopsy Profiling. [PDF]

Diagnostics (Basel)
Boscolo Bragadin A, Tosello V, Longo S, Padovan A, Baldissin S, Del Bianco P, Masetto E, Callegarin F, Bonanno L, Pasello G, Guarneri V, Indraccolo S.   +11 more
europepmc   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Secondary and Early Latent Syphilis in Adults. [PDF]

Open Forum Infect Dis
Chou C, Morton SR, Konda KA, Vargas S, Reyes-Diaz M, Vasquez F, Caceres CF, Klausner JD, Toombs T, Ahmad R, Allan-Blitz LT.   +10 more
europepmc   +1 more source

Wafer‐Scale Atomically‐Thin Gold: Transferable Platform for Flexible Optoelectronics, Thermal Management and Bio‐Interfaces

Advanced Science, EarlyView.
Combining template stripping with a graphene‐inspired transfer yields continuous, transferable gold films at 6‐inch wafer scale with thicknesses approaching the atomic limit. The atomically smooth, near‐bulk‐quality films offer above 86% transmittance and sub‐20 Ω/square sheet resistance, serving as a universal platform for flexible optoelectronics ...
Dmitry Yakubovsky, Mikhail Mironov, Georgy Ermolaev, Aleksandr Khrebtov, Aleksandr Slavich, Prashant Narute, Pritom Chowdhury, Roman Kirtaev, Igor Khramtsov, Anton Minnekhanov, Gleb Tselikov, Dmitriy Grudinin, Maria Sidorova, Nikolay Pak, Pavel Maslov, Andrey Vyshnevyy, Hongkai Zhou, Vasyl G. Kravets, Alexander N. Grigorenko, Ivan Kruglov, Nikita Orekhov, Dmitry Kireev, Aleksey Arsenin, Kostya S. Novoselov, Valentyn Volkov   +24 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Plasma Fibrinogen at Recurrence as a Prognostic Blood Biomarker in Oral Cavity Squamous Cell Carcinoma. [PDF]

Diagnostics (Basel)
Gómez-Fernández R, Vallejo-Díez J, Zarauza-Santos B, Burgos-Vico B, Heras-Losada SL, Redondo-González LM.   +5 more
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Exploring longitudinal relationships among Alzheimer's disease biomarkers. [PDF]

Alzheimers Dement
Saef B, Petersen KK, Volluz K, Li Y, Tosun D, Mila-Aloma M, Shaw LM, Zetterberg H, Dage JL, Rubel CE, Ferber K, Du-Cuny L, Coomaraswamy J, Baratta M, Mordashova Y, Saad ZS, Triana-Baltzer G, Ashton NJ, Meyers EA, Rosenbaugh EG, Sabandal JM, Bannon AW, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team, Schindler SE.   +25 more
europepmc   +1 more source