Results 31 to 40 of about 127,246 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Edge radial electric field in positive and negative triangularity plasmas in the TCV tokamak

Nuclear Fusion
We present the first edge E _r measurements in negative triangularity (NT) plasmas in the Tokamak à Configuration Variable (TCV). The Doppler backscattering measurements of $v_\perp \approx E_r/B$ reveal a significant impact of triangularity on the E _r ...
S. Rienäcker, P. Hennequin, L. Vermare, C. Honoré, R. Bouffet-Klein, S. Coda, B. Labit, B. Vincent, K.E. Thome, O. Krutkin, A. Balestri, Y. Nakeva, the TCV Team   +12 more
doaj   +1 more source

Influence of the Active Screen on the Embrittlement of a Plasma-Nitrided Edge [PDF]

Materials Research
In plasma nitriding of cutting tools, edge embrittlement can result from both, deepest layer, and grain boundaries precipitation. Overheating and surface charge density concentration in Direct Current Plasma Nitrided (DCPN) can be reduced through an ...
Júlio Azambuja da Silveira, Julio Cesar Klein das Neves, Leonardo Fonseca de Oliveira, Alexandre da Silva Rocha   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Experimental characterization of the edge fluctuations during I-phase at ASDEX Upgrade

Nuclear Fusion
The intermediate phase (I-phase) is a plasma regime that exists at the transition from the low-confinement mode (L-mode) to the fully developed high-confinement mode (H-mode), or vice versa.
J. Kalis, G. Birkenmeier, M. Griener, G. Grenfell, E. Wolfrum, M. Willensdorfer, J. Adamek, U. Stroth, the ASDEX Upgrade Team   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The quasi-continuous exhaust regime in JET

Nuclear Fusion
The quasi-continuous exhaust (QCE) regime is a regime that is naturally type-I ELM-free. It combines the high density at the plasma edge needed for power exhaust with the high normalised energy confinement typical for H-mode operation.
M. Faitsch, M. Dunne, E. Lerche, P. Lomas, I. Balboa, P. Bilkova, P. Bohm, A. Kappatou, D. Kos, B. Labit, S. Menmuir, O. Sauter, S. Silburn, E.R. Solano, H.J. Sun, A. Tookey, E. Viezzer, U. Stroth, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

Tokamak Edge Plasma Turbulence Interaction with Magnetic X-Point in 3D Global Simulations

Fluids, 2019
Turbulence in the edge plasma of a tokamak is a key actor in the determination of the confinement properties. The divertor configuration seems to be beneficial for confinement, suggesting an effect on turbulence of the particular magnetic geometry ...
Davide Galassi, Guido Ciraolo, Patrick Tamain, Hugo Bufferand, Philippe Ghendrih, Nicolas Nace, Eric Serre   +6 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison of divertor seed impurity gases retention efficiency by SOLPS-ITER modeling

Nuclear Fusion
In the paper a SOLPS-ITER modeling of H-Mode scenarios with different seed impurity gases (N, Ne, Ar, Kr) is performed for ASDEX Upgrade geometry. These gases are compared from the point of view of their radiation efficiency and compression in the ...
I.Yu. Senichenkov, A.G. Poletaeva, E.G. Kaveeva, I.Yu. Veselova, A.R. Nichik, V.A. Rozhansky   +5 more
doaj   +1 more source