Results 41 to 50 of about 127,246 (266)

Statistical model for intermittent plasma edge turbulence [PDF]

Physical Review E, 2005
The Probability Distribution Function of plasma density fluctuations at the edge of fusion devices is known to be skewed and strongly non-Gaussian. The causes of this peculiar behaviour are, up to now, largely unexplored. On the other hand, understanding the origin and the properties of edge turbulence is a key issue in magnetic fusion research.
Sattin F, Vianello N
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Characterization of hydrogen plasma defined graphene edges [PDF]

Carbon, 2019
10 pages, 7 ...
Mirko K. Rehmann, Yemliha B. Kalyoncu, Marcin Kisiel, Nikola Pascher, Franz J. Giessibl, Fabian Müller, Kenji Watanabe, Takashi Taniguchi, Ernst Meyer, Ming-Hao Liu, Dominik M. Zumbühl   +10 more
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Doubling fusion power with volumetric optimization in magnetic confinement fusion devices

Physical Review Research
A technique, volumetric power optimization, is presented for enhancing the power output of magnetic confinement fusion devices. Applied to a tokamak, this approach involves shifting the burning plasma region to a larger plasma volume while introducing ...
J. F. Parisi, J. W. Berkery, A. Sladkomedova, S. Guizzo, M. R. Hardman, J. R. Ball, A. O. Nelson, S. M. Kaye, M. Anastopoulos-Tzanis, S. A. M. McNamara, J. Dominski, S. Janhunen, M. Romanelli, D. Dickinson, A. Diallo, A. Dnestrovskii, W. Guttenfelder, C. Hansen, O. Myatra, H. R. Wilson   +19 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Gas puff imaging measurements during resonant magnetic perturbations on the HL-2A tokamak

Nuclear Fusion, 2023
The gas puff imaging diagnostic is used for the investigation of the poloidal flow and turbulent fluctuations at the plasma edge and scrape-off layer (SOL) on the HL-2A tokamak.
J.B. Yuan, M. Xu, Y. Yu, B.D Yuan, L. Nie, Z.H. Wang, T.F. Sun, T. Wu, R. Ke, T. Long, S.B. Gong, X.Q. Ji, J.Q. Li, HL-2A team   +13 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source