Results 31 to 40 of about 122,751 (265)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Ion and electron heating via magnetic reconnection during merging/compression plasma startup in ST40

Nuclear Fusion
Here, we report the latest results on the high-field application of a merging/compression (M/C) plasma startup in the ST40 spherical tokamak, using 96-channel 2D ion Doppler tomography and 30-channel Thomson scattering diagnostics installed over the past
H. Tanabe, R. Someya, T. Ahmadi, M.P. Gryaznevich, H.V. Willett, D. Osin, H.F. Lowe, H. Bohlin, T. O’Gorman, J. Wood, A. Rengle, S.A.M. McNamara, P.F. Buxton, O. Asunta, Y. Takase, J. Luo, S. Kobayashi, M. Inomoto, Y. Ono   +18 more
doaj   +1 more source

Specific Heat of Electron Plasma Waves

Physical Review Letters, 2023
Collective modes in a plasma, like phonons in a solid, contribute to a material's equation of state and transport properties, but the long wavelengths of these modes are difficult to simulate with today's finite-size quantum simulation techniques. A simple Debye-type calculation of the specific heat of electron plasma waves is presented, yielding up to
J. R. Rygg, P. M. Celliers, G. W. Collins   +2 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Real-time capable modeling of ICRF heating on NSTX and WEST via machine learning approaches

Nuclear Fusion
A real-time capable core Ion Cyclotron Range of Frequencies (ICRF) heating model on NSTX and WEST is developed. The model is based on two nonlinear regression algorithms, the random forest ensemble of decision trees and the multilayer perceptron neural ...
Á. Sánchez-Villar, Z. Bai, N. Bertelli, E.W. Bethel, J. Hillairet, T. Perciano, S. Shiraiwa, G.M. Wallace, J.C. Wright   +8 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Heating in Toroidal Plasmas

Kakuyūgō kenkyū, 1984
炉心プラズマを核融合反応が持続する点火温度にまで加熱するためには, 高速中性粒子束あるいは高周波波動をプラズマに入射し, 中心部に伝送して, それが吸収され, プラズマのエネルギーとして蓄えられることが必要である。また, その運動量をプラズマ粒子に与えて非誘導駆動電流を発生し得れば, 定常トカマク炉の実現も想定される。これらのプラズマ加熱法及び電流駆動法の物理機構, 研究の概要について述べる。
Tanaka, Shigetoshi, Kuroda, Tsutomu, Odajima, Kazuo   +2 more
openaire   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Electron energization and mixing observed by MMS in the vicinity of an electron diffusion region during magnetopause reconnection

Geophysical Research Letters, 2016
Measurements from the Magnetospheric Multiscale (MMS) mission are reported to show distinct features of electron energization and mixing in the diffusion region of the terrestrial magnetopause reconnection.
Li‐Jen Chen, Michael Hesse, Shan Wang, Daniel Gershman, Robert Ergun, Craig Pollock, Roy Torbert, Naoki Bessho, William Daughton, John Dorelli, Barbara Giles, Robert Strangeway, Christopher Russell, Yuri Khotyaintsev, Jim Burch, Thomas Moore, Benoit Lavraud, Tai Phan, Levon Avanov   +18 more
doaj   +1 more source