Results 61 to 70 of about 404,814 (301)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Iterative addition of parallel non-local effects to full wave ICRF finite element models in axisymmetric tokamak plasmas

Nuclear Fusion
The current response of a hot magnetized plasma to a radio-frequency wave is non-local, turning the electromagnetic wave equation into an integro-differential equation. Non-local physics gives rise to wave physics and absorption processes not observed in
B. Zaar, T. Johnson, R. Bilato, P. Vallejos   +3 more
doaj   +1 more source

Recent Progress in ICRF Experiments on the Experimental Advanced Superconducting Tokamak (EAST) [PDF]

EPJ Web of Conferences
Ion Cyclotron Range of Frequency (ICRF) heating is a major auxiliary heating method used on the Experimental Advanced Superconducting Tokamak (EAST). This paper summarizes recent progress in ICRF experiments on EAST, including the upgrade of ICRF heating
Zhang Wei, Antar Ghassan, Cheng Yan, Deng Xu, Ju Songqing, Kazakov Yevgen, Liu Lunan, Mao Yuzhou, Ongena Jozef, Qin Chengming, Wang Lei, Wang Yongsheng, Wouters Tom, Yang Hua, Yuan Shuai, Zhang Kai, Zhang Xinjun   +16 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Connection between Polytropic Index and Heating

The Astrophysical Journal, 2023
The paper derives the one-to-one connecting relationships between plasma heating and its polytropic index, and addresses the consequences through the transport equation of temperature.
G. Livadiotis, D. J. McComas
doaj   +1 more source

Two-fluid and magnetohydrodynamic modelling of magnetic reconnection in the MAST spherical tokamak and the solar corona

, 2015
Twisted magnetic flux ropes are ubiquitous in space and laboratory plasmas, and the merging of such flux ropes through magnetic reconnection is an important mechanism for restructuring magnetic fields and releasing free magnetic energy.
Browning, P. K., Cardnell, S., Evans, M., Lucini, F. Arese, Lukin, V. S., McClements, K. G., Stanier, A.   +6 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Observation of isotropic electron temperature in the turbulent E region [PDF]

Annales Geophysicae, 2001
Using EISCAT radar data, we find that electrons are strongly heated in the magnetic field-line direction during high electric field events. The remote site data show that the electron temperature increases in almost the same way in the field ...
S. Saito, S. Saito, S. C. Buchert, S. Nozawa, R. Fujii   +4 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion [PDF]

, 2012
Copyright @ 2012 The AuthorsThis article has been made available through the Brunel Open Access Publishing Fund.Human limb muscle and skin blood flow increases significantly with elevations in temperature, possibly through physiological processes that ...
Abraham, Akyurekli, Baar, Barcroft, Bazett, Bergfeld, Black, Cheng, Coade, Cripps, Denning, Deussen, Dill, Duc, Dufour, Ellsworth, Feliciano, Fischer, González-Alonso, González-Alonso, González-Alonso, Gordon, Gorman, Gorman, Gourine, Green, He, José González-Alonso, Kameljit K. Kalsi, Keller, Kirby, Kirby, Llaudet, Locovei, Malinauskas, Mortensen, Mortensen, Mortensen, Niimi, Olearczyk, Pearson, Ray, Rosenmeier, Rowell, Ruiter, Saltin, Schrage, Scott-Ward, Sheppard, Sprague, Sprague, Sridharan, Sterling, Tu, Williamson, Yegutkin, Yegutkin, Zimmermann, Zimmermann   +58 more
core   +2 more sources