Results 41 to 50 of about 515,702 (289)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
3D Radio and X-Ray Modeling and Data Analysis Software: Revealing Flare Complexity [PDF]
, 2015 We have undertaken a major enhancement of our IDL-based simulation tools developed earlier for modeling microwave and X-ray emission. The object-based architecture provides an interactive graphical user interface that allows the user to import ...
Fleishman, Gregory D. +4 more
core +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Non-Axisymmetric Tokamak Plasma Equilibrium by 3-D Multi-Layers Method
Applied SciencesA three-dimensional (3-D) Multi-Layers Method (MLM) of an extension of the axisymmetric version has been developed to compute non-axisymmetric tokamak plasma equilibria with a separatrix.
Jingting Wang, Hiroaki Tsutsui
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Using LQR controller for vertical position control on EAST
Nuclear FusionVertical position control is essential for stabilizing plasma with elongated configurations. The EAST tokamak is equipped with a set of in-vessel control (IC) coils dedicated to this purpose.
Wangyi Rui +8 more
doaj +1 more source
Dynamic Formation of a Transient Jet from Arched Magnetized Laboratory Plasma
The Astrophysical Journal, 2023 A laboratory plasma experiment was built to explore the eruptive behavior of arched magnetized plasmas with dimensionless parameters relevant to the Sun’s photosphere ( β ≈ 10 ^−3 , Lundquist number ≈10 ^4 , plasma radius/ion gyroradius ≈20, ion–neutral ...
Kamil D. Sklodowski +2 more
doaj +1 more source
The Heavy-Ion Beam Diagnostic of the ISTTOK Tokamak—Highlights and Recent Developments
Sensors, 2022 The unique arrangement of the heavy-ion beam diagnostic in ISTTOK enables one to measure the evolution of temperature, density and pressure-like profiles in normal and AC discharges. The fast chopping beam technique provided the possibility to reduce the
A. Malaquias +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source