QSAR Models for the Prediction of Plasma Protein Binding [PDF]
BioImpacts, 2013 Introduction: The prediction of plasma protein binding (ppb) is of paramount importance in the pharmacokinetics characterization of drugs, as it causes significant changes in volume of distribution, clearance and drug half life.
Zeshan Amin, Taravat Ghafourian
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Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry [PDF]
Frontiers in Pharmacology, 2022 Objective: Curcumol is one of the major active ingredients isolated from the traditional Chinese medicine Curcumae Rhizoma and is reported to exhibit various bioactivities, such as anti-tumor and anti-liver fibrosis effects.
Zhaoxu Yang +20 more
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A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests [PDF]
PharmaceuticsObjectives: Ultrafiltration (UF) is widely accepted as a method for assessing the plasma protein binding (PPB) of drugs. However, it is vulnerable to non-specific binding (NSB) to the device, which can result in inaccuracies.
Sang Ho Jeon +7 more
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Plasma Protein Binding Rate and Pharmacokinetics of Lekethromycin in Rats [PDF]
Antibiotics, 2022 Lekethromycin (LKMS), a novel macrolide lactone, is still unclear regarding its absorption. Thus, we conducted this study to investigate the characteristics of LKMS in rats.
Pan Sun +6 more
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Non-linear plasma protein binding of cannabidiol [PDF]
Journal of Cannabis ResearchBackground Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications.
Mariana Babayeva, Iva Srdanovic
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Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method [PDF]
Frontiers in PharmacologyIntroductionPlasma protein binding plays a significant role in influencing the pharmacokinetic and pharmacodynamic properties of drugs. This study focuses on examining two pairs of sequence-matched ASOs: phosphorodiamidate morpholino oligomers (PMOs) and
Cassandra Yun +3 more
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Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate [PDF]
Frontiers in Pharmacology, 2022 Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC50 0.078 nM), and thus has antitumor drug development prospects.
Jiahong Xiang +20 more
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Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing [PDF]
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
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Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy [PDF]
PharmaceuticsBackground/Objectives: Triple-negative breast cancer (TNBC) is a major cause of cancer-related deaths among women. The Hedgehog (Hh) signaling pathway plays a critical role in tumor development, and targeting this pathway may provide new therapeutic ...
Dingsheng Wen +4 more
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