Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry [PDF]
Frontiers in Pharmacology, 2022 Objective: Curcumol is one of the major active ingredients isolated from the traditional Chinese medicine Curcumae Rhizoma and is reported to exhibit various bioactivities, such as anti-tumor and anti-liver fibrosis effects.
Zhaoxu Yang +20 more
doaj +2 more sources
Developmental changes in the extent of drug binding to rat plasma proteins
Scientific Reports, 2023 Binding of therapeutics to proteins in blood plasma is important in influencing their distribution as it is their free (unbound) form that is able to cross cellular membranes to enter tissues and exert their actions.
Fiona Qiu +5 more
doaj +1 more source
An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans +8 more
doaj +1 more source
Estimation of angiotensin-converting enzyme inhibitors protein binding degree using chromatographic hydrophobicity data [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2015 Introduction. Angiotensin-converting enzyme (ACE) inhibitors represent a significant group of drugs primarily used in the treatment of hypertension and congestive heart failure. Objective.
Trbojević-Stanković Jasna +2 more
doaj +1 more source
Binding and sequestration of poison frog alkaloids by a plasma globulin
eLife, 2023 Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation.
Aurora Alvarez-Buylla +9 more
doaj +1 more source
Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury [PDF]
PeerJ, 2020 Background Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens ...
Sahra Pajenda +6 more
doaj +2 more sources
Animals, 2022 Sperm-neutrophil binding is an important facet of breeding and significantly impacts fertility. While a specific seminal plasma protein has been found to reduce this binding and improve fertility (CRISP-3), additional molecule(s) appear to promote ...
Abdorrahman S. Alghamdi +7 more
doaj +1 more source
Investigating the side-chain structural organization behind the stability of protein folding and binding [PDF]
Sci Rep 12, 12087 (2022), 2021 What are the molecular mechanisms that dictate protein-protein binding stability and whether those are related to the ones behind protein fold stability are still largely open questions. Indeed, despite many past efforts, we still lack definitive models to account for experimental quantities like protein melting temperature or complex binding affinity.
arxiv +1 more source
Ligand-induced protein dynamics differences correlate with protein-ligand binding affinities: An unsupervised deep learning approach [PDF]
Commun. Biol. 5, 481 (2022), 2021 Prediction of protein-ligand binding affinity is a major goal in drug discovery. Generally, free energy gap is calculated between two states (e.g., ligand binding and unbinding). The energy gap implicitly includes the effects of changes in protein dynamics induced by the binding ligand.
arxiv +1 more source