Results 131 to 140 of about 1,339,631 (349)
Binding of digitoxin and some related cardenolides to human plasma proteins [PDF]
, 1969 Daniel S. Lukas, Anthony G. De Martino
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich +10 more
wiley +1 more source
A Quantitative Structure-Activity Relationship for Human Plasma Protein Binding: Prediction, Validation and Applicability Domain. [PDF]
Adv Pharm Bull, 2023 Khaouane A, Ferhat S, Hanini S.
europepmc +1 more source
TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA. III. THE EFFECTS OF VARIOUS STEROIDS *† [PDF]
, 1960 Avery A. Sandberg +2 more
openalex +1 more source
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA. V. IN VITRO INHIBITION OF CORTISOL METABOLISM* [PDF]
, 1963 Avery A. Sandberg, W. Roy Slaunwhite
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics. [PDF]
Nucleic Acids Res, 2022 Humphreys SC +12 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source
Acta Medica Iranica, 2016 Pneumococcal autolysins are enzymes involved in cell wall turnover and cellular division physiologically. They have been found to be involved in the pneumococcus pathogenesis.
Ramina Mahboobi +3 more
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