Results 161 to 170 of about 2,396,679 (391)

Plasma protein binding prediction focusing on residue-level features and circularity of cyclic peptides by deep learning. [PDF]

Bioinformatics, 2022
Li J, Yanagisawa K, Yoshikawa Y, Ohue M, Akiyama Y.   +4 more
europepmc   +1 more source

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

Characterization of Afb, a novel bifunctional protein in Streptococcus agalactiae

Iranian Journal of Microbiology, 2016
Background and Objectives: Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis in newborns and results in pneumonia and bacteremia in adults. A number of S.
Sanaz Dehbashi, Mohamad Reza Pourmand, Rahil Mashhadi   +2 more
doaj  

Neglecting Plasma Protein Binding in COVID-19 Patients Leads to a Wrong Interpretation of Lopinavir Overexposure. [PDF]

Clin Pharmacol Ther, 2021
Stanke-Labesque F, Concordet D, Djerada Z, Bouchet S, Solas C, Mériglier E, Bonnet F, Mourvillier B, Ruiz S, Martin-Blondel G, Epaulard O, Schwebel C, Gautier-Veyret E, Gandia P.   +13 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Evaluation of Quantitative Structure Property Relationship Algorithms for Predicting Plasma Protein Binding in Humans. [PDF]

Comput Toxicol, 2021
Yun YE, Tornero-Velez R, Purucker ST, Chang DT, Edginton AN.   +4 more
europepmc   +1 more source

Diphenylhydantoin Binding to Proteins in Plasma and Its Dependence on Free Fatty Acid and Bilirubin Concentration in Dogs and Newborn Infants [PDF]

, 1975
Bertil B. Fredholm, Anders Rane, Bertil Persson   +2 more
openalex   +1 more source

The binding of dyestuffs by proteins [PDF]

, 1950
Thesis (M.A.)--Boston ...
Scully, Margaret A
core   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Ultrastructural localization of plasma retinol-binding protein in rat liver

Journal of Lipid Research, 1990
Immunocytochemical studies were carried out to examine the subcellular localization of plasma retinol-binding protein (RBP) in rat liver. The studies used normal, retinol-deficient, and retinol-repleted retinol-deficient rats with or without colchicine ...
A Suhara, M Kato, M Kanai
doaj