In Vitro Protein Binding of Liraglutide in Human Plasma Determined by Reiterated Stepwise Equilibrium Dialysis [PDF]
Journal of Pharmacy and Science, 2013 Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue approved for the treatment of type 2 diabetes. It is based on human GLP-1 with the addition of a 16-carbon fatty acid, which facilitates binding to plasma proteins, thus prolonging the ...
Jensen, Lisbeth Bjerring +2 more
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Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics. [PDF]
Nucleic Acids Res, 2022 At the time of writing, although siRNA therapeutics are approved for human use, no official regulatory guidance specific to this modality is available. In the absence of guidance, preclinical development for siRNA followed a hybrid of the small molecule ...
Humphreys SC +12 more
europepmc +2 more sources
Plasma protein binding of chlorpromazine
Journal of Pharmacy and Pharmacology, 1970 AbstractMore than 90% of the plasma content of chlorpromazine over a concentration range from 0·008 to 15·1 μg/ml was bound to human plasma protein. Binding was affected by the pH of the aqueous medium; with few exceptions the higher values were obtained at the higher pH values.
S. Curry
openaire +4 more sources
TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA*† [PDF]
Journal of Clinical Investigation, 1959 W. Roy Slaunwhite, Avery A. Sandberg
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Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. [PDF]
J Med Chem, 2020 Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding and metabolic stability.
Obeng S +13 more
europepmc +2 more sources
Ultrafiltration Method for Plasma Protein Binding Studies and Its Limitations
Processes, 2021 Plasma protein binding plays a critical role in drug therapy, being a key part in the characterization of any compound. Among other methods, this process is largely studied by ultrafiltration based on its advantages.
C. Toma +4 more
semanticscholar +1 more source
Developmental changes in the extent of drug binding to rat plasma proteins
Scientific Reports, 2023 Binding of therapeutics to proteins in blood plasma is important in influencing their distribution as it is their free (unbound) form that is able to cross cellular membranes to enter tissues and exert their actions.
Fiona Qiu +5 more
doaj +1 more source
Drug Distribution Part 2. Predicting Volume of Distribution from Plasma Protein Binding and Membrane Partitioning. [PDF]
Pharm Res, 2017 Korzekwa K, Nagar S.
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An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans +8 more
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Characterization of plasma protein binding dissociation with online SPE-HPLC. [PDF]
Sci Rep, 2015 A novel parameter of relative recovery (Rre) was defined and determined by online SPE-HPLC to characterize plasma protein binding (PPB) kinetics of highly plasma binding drugs.
Li P, Fan Y, Wang Y, Lu Y, Yin Z.
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