Plasma Protein Binding Rate and Pharmacokinetics of Lekethromycin in Rats [PDF]
Antibiotics, 2022 Lekethromycin (LKMS), a novel macrolide lactone, is still unclear regarding its absorption. Thus, we conducted this study to investigate the characteristics of LKMS in rats.
Pan Sun +6 more
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A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests [PDF]
PharmaceuticsObjectives: Ultrafiltration (UF) is widely accepted as a method for assessing the plasma protein binding (PPB) of drugs. However, it is vulnerable to non-specific binding (NSB) to the device, which can result in inaccuracies.
Sang Ho Jeon +7 more
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Non-linear plasma protein binding of cannabidiol [PDF]
Journal of Cannabis ResearchBackground Cannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result in alteration of pharmacological activity of cannabidiol-containing medications.
Mariana Babayeva, Iva Srdanovic
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Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method [PDF]
Frontiers in PharmacologyIntroductionPlasma protein binding plays a significant role in influencing the pharmacokinetic and pharmacodynamic properties of drugs. This study focuses on examining two pairs of sequence-matched ASOs: phosphorodiamidate morpholino oligomers (PMOs) and
Cassandra Yun +3 more
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Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate [PDF]
Frontiers in Pharmacology, 2022 Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC50 0.078 nM), and thus has antitumor drug development prospects.
Jiahong Xiang +20 more
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Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing [PDF]
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
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QSAR Models for the Prediction of Plasma Protein Binding [PDF]
BioImpacts, 2013 Introduction: The prediction of plasma protein binding (ppb) is of paramount importance in the pharmacokinetics characterization of drugs, as it causes significant changes in volume of distribution, clearance and drug half life.
Zeshan Amin, Taravat Ghafourian
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Binding of Hepcidin to Plasma Proteins [PDF]
Clinical Chemistry, 2012 To the Editor: The hepcidin hormone of 25 amino acid residues is a key regulator of iron homeostasis (1). Hepcidin has been shown to bind in vitro to α2-macroglobulin (α2M)1 and albumin in human plasma (2). It is not known, however, to what extent hepcidin is bound to proteins in vivo.
Rabah Soliymani +5 more
openaire +3 more sources
Nanomaterials, 2023 Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio +3 more
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Transcutaneous application of ultrasound enhances the effects of finasteride in a murine model of androgenic alopecia [PDF]
Ultrasonography, 2022 Purpose The purpose of this study was to evaluate if transcutaneous application of low-intensity ultrasound can locally enhance the effects of finasteride on hair growth in a murine model of androgenic alopecia (AA).
Jaeho Kim +4 more
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