Results 11 to 20 of about 1,339,631 (349)

Developmental changes in the extent of drug binding to rat plasma proteins

Scientific Reports, 2023
Binding of therapeutics to proteins in blood plasma is important in influencing their distribution as it is their free (unbound) form that is able to cross cellular membranes to enter tissues and exert their actions.
Fiona Qiu, Katarzyna M. Dziegielewska, Yifan Huang, Mark D. Habgood, Georgia Fitzpatrick, Norman R. Saunders   +5 more
doaj   +1 more source

Binding of Hepcidin to Plasma Proteins [PDF]

Clinical Chemistry, 2012
To the Editor: The hepcidin hormone of 25 amino acid residues is a key regulator of iron homeostasis (1). Hepcidin has been shown to bind in vitro to α2-macroglobulin (α2M)1 and albumin in human plasma (2). It is not known, however, to what extent hepcidin is bound to proteins in vivo.
Hämäläinen Esa, Parkkinen Jaakko, Baumann Marc, Itkonen Outi, Soliymani Rabah, Stenman Ulf Håkan, Hämäläinen Esa, Parkkinen Jaakko, Baumann Marc, Itkonen Outi, Soliymani Rabah, Stenman Ulf Håkan   +11 more
openaire   +3 more sources

An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review

Frontiers in Pharmacology, 2022
Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans, A. E. Muller, A. E. Muller, P. Van Den Broek, B. De Melo Cruz De Almeida, C. Van Den Berg, J. Van Oldenrijk, P. K. Bos, B. C. P. Koch   +8 more
doaj   +1 more source

Estimation of angiotensin-converting enzyme inhibitors protein binding degree using chromatographic hydrophobicity data [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
Introduction. Angiotensin-converting enzyme (ACE) inhibitors represent a significant group of drugs primarily used in the treatment of hypertension and congestive heart failure. Objective.
Trbojević-Stanković Jasna, Aleksić Mirjana, Odović Jadranka   +2 more
doaj   +1 more source

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Assink, Y., Berg, J.H.J. van den, Bergman, A., Brouwer, A., Cenijn, P.H., Koeman, J.H., Meerts, I.A.T.M., Weijers, B.M.   +7 more
core   +15 more sources

Binding and sequestration of poison frog alkaloids by a plasma globulin

eLife, 2023
Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation.
Aurora Alvarez-Buylla, Marie-Therese Fischer, Maria Dolores Moya Garzon, Alexandra E Rangel, Elicio E Tapia, Julia T Tanzo, H Tom Soh, Luis A Coloma, Jonathan Z Long, Lauren A O'Connell   +9 more
doaj   +1 more source

Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury [PDF]

PeerJ, 2020
Background Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens ...
Sahra Pajenda, Andreja Figurek, Ludwig Wagner, Daniela Gerges, Alice Schmidt, Harald Herkner, Wolfgang Winnicki   +6 more
doaj   +2 more sources

Binding of Equine Seminal Lactoferrin/Superoxide Dismutase (SOD-3) Complex Is Biased towards Dead Spermatozoa

Animals, 2022
Sperm-neutrophil binding is an important facet of breeding and significantly impacts fertility. While a specific seminal plasma protein has been found to reduce this binding and improve fertility (CRISP-3), additional molecule(s) appear to promote ...
Abdorrahman S. Alghamdi, Carleigh E. Fedorka, Kirsten E. Scoggin, Alejandro Esteller-Vico, Kaylin Beatty, Gabriel Davolli, Barry A. Ball, Mats H. T. Troedsson   +7 more
doaj   +1 more source

Exploiting Blood Transport Proteins as Carborane Supramolecular Vehicles for Boron Neutron Capture Therapy

Nanomaterials, 2023
Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio, Edoardo Jun Mattioli, Francesco Zerbetto, Matteo Calvaresi   +3 more
doaj   +1 more source

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury [PDF]

, 2013
Background: Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure.
A Linder, Cecilia M O’Kane, Daniel F McAuley, DF McAuley, DG Sinclair, G Weitz-Schmidt, H Herwald, H Sengelov, H Tapper, Heiko Herwald, J Grommes, JR Jacobson, K Tsushima, Karim Dib, KP Steinberg, M Shyamsundar, MB Fessler, MS Chew, MS Diamond, Murali Shyamsundar, N Gautam, O Soehnlein, O Soehnlein, S Steiner, S Zhang, Thelma R Craig, TR Craig, WM Shafer   +27 more
core   +1 more source