Tailoring the Properties of Functional Materials With N‐Oxides
Advanced Functional Materials, EarlyView.The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich +5 more
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Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy. [PDF]
PharmaceuticsWen D, Chen B, Deng M, Wu S, Xie S.
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Distinct binding strategies of plasma proteins on gold surfaces: flexibility versus stability in the protein corona formation [PDF]
Beatrice Cipriani +2 more
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Prediction of drug concentrations in human skim milk from plasma protein binding and acid‐base characteristics. [PDF]
, 1988 HC Atkinson, EJ Begg
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Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
Advanced Functional Materials, EarlyView.To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
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Advanced Functional Materials, EarlyView.This work reveals a fundamental trade‐off between plasmonic and dielectric metasurfaces for molecular sensing. A clear performance crossover is identified: dielectric metasurfaces excel in air, while plasmonic metasurfaces dominate in lossy solvents. These results establish design rules for infrared metasurface sensors and enable optimized performance ...
Tao Jiang +8 more
wiley +1 more source
Environmentally Friendly Fluoroquinolone Derivatives with Lower Plasma Protein Binding Rate Designed Using 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation. [PDF]
Int J Environ Res Public Health, 2020 Hou Y, Zhao Y, Li Y.
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Tenidap sodium does not alter the clearance or plasma protein binding of tolbutamide in healthy male volunteers. [PDF]
, 1995 K. Wilner, M. J. Gardner
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Multifunctional Microstructured Surfaces by Microcontact Printing of Reactive Microgels
Advanced Functional Materials, EarlyView.Reactive poly(N‐vinylcaprolactam‐co‐glycidyl methacrylate) microgels are used as functional inks to create surface‐grafted arrays on glass via microcontact printing. The patterns (10–50 µm widths and spacings) enable stable binding and post‐functionalization with dyes and peptides.
Inga Litzen +4 more
wiley +1 more source
Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone. [PDF]
Pharmaceutics, 2020 Zheng YF +9 more
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