Results 21 to 30 of about 780,315 (335)
Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
doaj +1 more source
Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]
Soft Matter 18, 3384-3394 (2022), 2022 Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
arxiv +1 more source
Coarse-grained model of adsorption of blood plasma proteins onto nanoparticles [PDF]
Journal of Chemical Physics 143 (24), 243138, 2015, 2015 We present a coarse-grained model for evaluation of interactions of globular proteins with nanoparticles. The protein molecules are represented by one bead per aminoacid and the nanoparticle by a homogeneous sphere that interacts with the aminoacids via a central force that depends on the nanoparticle size.
arxiv +1 more source
Photoaffinity Labeling of Plasma Proteins
Molecules, 2013 Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling.
Masaki Otagiri, Victor Tuan Giam Chuang
doaj +1 more source
Molecules, 2022 PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time.
Guru R. Valicherla +8 more
doaj +1 more source
Biophysica, 2021 A dataset containing the experimental values of the equilibrium binding constants of clinical drugs, and some other organic ligands with human and mammalian (predominantly bovine) serum albumins, is assembled.
Igor Sedov +2 more
doaj +1 more source
A mini-review of the diffusion dynamics of DNA-binding proteins: Experiments and models [PDF]
, 2020 In the course of various biological processes, specific DNA-binding proteins must find a particular target sequence/protein or a damaged site on the DNA efficiently. DNA-binding proteins perform this task based on diffusion. Yet, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated ...
arxiv +1 more source
Chemistry Central Journal, 2018 Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years.
Qishu Jiao +3 more
doaj +1 more source
Space Layout of Low-entropy Hydration Shells Guides Protein Binding [PDF]
arXiv, 2022 Protein-protein binding enables orderly and lawful biological self-organization, and is therefore considered a miracle of nature. Protein-protein binding is steered by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions.
arxiv
The binding of flurbiprofen to plasma proteins
Journal of Pharmacy and Pharmacology, 1985 Abstract The binding of flurbiprofen to human serum albumin and normal plasma was measured using ultracentrifugation. Flurbiprofen was bound in excess of 99% in all cases. Over the concentration range normally associated with therapy the data could be adequately described by a one-site binding model.
Masooma Alam‐Siddiqi +3 more
openaire +3 more sources