Estimation of angiotensin-converting enzyme inhibitors protein binding degree using chromatographic hydrophobicity data [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2015 Introduction. Angiotensin-converting enzyme (ACE) inhibitors represent a significant group of drugs primarily used in the treatment of hypertension and congestive heart failure. Objective.
Trbojević-Stanković Jasna +2 more
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Binding and sequestration of poison frog alkaloids by a plasma globulin
eLife, 2023 Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation.
Aurora Alvarez-Buylla +9 more
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A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding. [PDF]
Biopharm Drug Dispos, 2016 Ye M, Nagar S, Korzekwa K.
europepmc +2 more sources
Animals, 2022 Sperm-neutrophil binding is an important facet of breeding and significantly impacts fertility. While a specific seminal plasma protein has been found to reduce this binding and improve fertility (CRISP-3), additional molecule(s) appear to promote ...
Abdorrahman S. Alghamdi +7 more
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Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury [PDF]
PeerJ, 2020 Background Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens ...
Sahra Pajenda +6 more
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Binding of Hepcidin to Plasma Proteins [PDF]
Clinical Chemistry, 2012 To the Editor: The hepcidin hormone of 25 amino acid residues is a key regulator of iron homeostasis (1). Hepcidin has been shown to bind in vitro to α2-macroglobulin (α2M)1 and albumin in human plasma (2). It is not known, however, to what extent hepcidin is bound to proteins in vivo.
Rabah Soliymani +5 more
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Nanomaterials, 2023 Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio +3 more
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RPE65 of Retinal Pigment Epithelium, A Putative Receptor Molecule for Plasma Retinol-Binding Protein, is Expressed in Human Keratinocytes [PDF]
, 2004 Retinoids are important modulators for cell growth and differentiation of normal skin. In plasma, retinol is transported coupled to plasma retinol-binding protein.
Brugger, Karin +6 more
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Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury [PDF]
, 2013 Background: Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure.
A Linder +27 more
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Experimental versus theoretical log D7.4, pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances [PDF]
, 2018 The misuse of benzodiazepines as new psychoactive substances is an increasing problem around the world. Basic physicochemical and pharmacokinetic data is required on these substances in order to interpret and predict their effects upon humans ...
Manchester, Kieran R. +2 more
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