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Plasma protein binding of phencyclidine
Clinical Pharmacology and Therapeutics, 1982In healthy male subjects (n = 12) phencyclidine (PCP) free fraction was 22.0 +/- 2.8 % (mean +/- SD). In male patients with mild to moderate alcoholic liver disease (n = 16) free fraction (23.0 +/- 3.4%) was of the same order as in healthy subjects although age and the concentrations of albumin, bilirubin, and high-density lipoproteins were different ...
William A. Corrigall +3 more
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The plasma protein binding of HIDA
European Journal of Nuclear Medicine, 1980By using Sephadex gel column chromatography to separate substances into their various components according to molecular weight, we have investigated the effect of incubating several "brands" of HIDA in plasma, in vitro. The results show that such incubation has no effect on either dimethyl HIDA, or diethyl HIDA, but that in the case of para-butyl HIDA,
R. W. Nicholson +3 more
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Oestriol binding to plasma proteins
Journal of Steroid Biochemistry, 1988Simple diffusion experiments indicated that oestriol was retained by human pregnancy plasma more effectively than by albumin solutions of a corresponding concentration. Oestriol bound (Ka = 6 X 10(6) l/mol at 4 degrees C) to a glycoprotein which had been isolated from plasma by adsorption to Concanavalin A.
R.E. Oakey, V. Moutsatsou
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The binding of cortisol by plasma protein
Archives of Biochemistry and Biophysics, 1958Abstract When plasma cortisol concentrations are less than 30 μg./100 ml., the steroid is tightly bound by protein and cannot be ultrafiltered. When the concentration is raised higher than 40 μg./100 ml., either by addition of exogenous cortisol in vitro or as a result of the effects of adrenocorticotropic hormone (ACTH) or of sickness on the ...
G. Virginia Upton, Philip K. Bondy
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Binding Affinities of Thyroxine-Binding Proteins in Turtle Plasma
General and Comparative Endocrinology, 1993Binding affinities (Ka) for thyroxine (T4) by blood plasma and purified plasma proteins from two turtles, the slider (Trachemys scripta) and snapper (Chelydra serpentina), were compared with those of a human using equilibrium dialysis. The purified T4 binding protein (TBP) from T.
Karen A. Glennemeier, Paul Licht
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The Binding of Urate to Plasma Proteins
1974Although the etiologic role of microcrystalline monosodium urate monohydrate in the pathogenesis of acute gouty arthritis has been well established, the mechanism by which urate precipitates in joints, soft tissues and the kidneys remains unclear. Some studies have suggested that the solubility of urate is the key factor and that when the solubility of
David S. Campion +3 more
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Mn++ BINDING BY PLASMA PROTEINS
International Journal of Peptide and Protein Research, 197354Mn2+ added to human or rabbit plasma in vitro combines selectively with the albumin fraction. At pH 7.0, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, where n1 = 1 and K1 = 2.4 × 104, the other where n2 = 0.5 and K2 = 0.5 × 103.Zn2+, Ni2+ and Co2+ can compete effectively for these sites.
Arvind K.N. Nandedkar +2 more
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Renin binding proteins in plasma
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1979Renin is found in mouse plasma as high molecular weight forms, in addition to the fully active 40 000 dalton form. By using freshly 125 I-labelled 40 000 dalton pure submaxillary mouse renin, no binding to plasma proteins was demonstrable. However, unfolding and refolding of the labelled renin by guanidine facilitated binding to specific mouse and ...
Christian Malling +4 more
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1992
Drugs used in anesthesia are all bound to a greater or lesser degree to plasma proteins. Plasma protein binding of drugs has a significant effect on their kinetics and dynamics. Variations of normal physiology and diseases affect both the concentrations and affinity of plasma proteins for drugs. This chapter provides a brief discussion of the relevance
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Drugs used in anesthesia are all bound to a greater or lesser degree to plasma proteins. Plasma protein binding of drugs has a significant effect on their kinetics and dynamics. Variations of normal physiology and diseases affect both the concentrations and affinity of plasma proteins for drugs. This chapter provides a brief discussion of the relevance
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Plasma Steroid-Binding Proteins
Endocrinology and Metabolism Clinics of North America, 1991Two steroid-binding proteins circulate in plasma, corticosteroid-binding globulin and sex hormone-binding globulin. They both have several different but connected, physiologic functions. Each is the major determinant of the concentration of the physiologically important hormones that they bind.
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