Results 311 to 320 of about 2,396,679 (391)

Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin.

ACS Infectious Diseases, 2017
Daptomycin is a lipopeptide antibiotic that is highly bound to plasma proteins. To date, the plasma components and structure-activity relationships responsible for the plasma protein binding profile of daptomycin remain uncharacterized.
E. Schneider, Johnny X. Huang, V. Carbone, M. Han, Yan Zhu, S. Nang, K. Khoo, J. Mak, M. Cooper, J. Li, T. Velkov   +10 more
semanticscholar   +1 more source

THE BINDING OF URATE BY PLASMA PROTEINS

Australian Journal of Experimental Biology and Medical Science, 1979
SummaryProtein binding of urate may have some pertinence to the pathogenesis of goat. However, binding studies have been hampered by problems with in vitro methodology and by the problem of relating the results of in vitro studies to the physiological situation.In the present study urate binding was determined by an ultrafiltration procedure.
John Rl Masarei, Joseph Bertolini
openaire   +3 more sources

Plasma Protein Binding of Bepridil

The Journal of Clinical Pharmacology, 1985
The binding of the calcium‐channel blocking agent, bepridil HCl (Vascor), to plasma proteins was investigated using radiolabeled bepridil and equilibrium dialysis. Greater than 99.7% of added bepridil‐14C was found to freshly collected human plasma. The binding was characterized by a saturable high‐affinity site (KD = 32 ng/mL = 87 nM) on alpha1‐acid ...
Barry H. Dvorchik, Linda A. McKown, J. Frederick Pritchard, Patrick J. O'Neill   +3 more
openaire   +3 more sources

Binding of flavonoids to plasma proteins

2001
International ...
Dangles, O., Dufour, C., Manach, Claudine, Morand, Christine, Remesy, Christian   +4 more
openaire   +4 more sources

The binding of ibuprofen to plasma proteins

European Journal of Clinical Pharmacology, 1983
The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty acid contamination of the human ...
M Siddiqui, D M Grennan, Leon Aarons
openaire   +3 more sources

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum.

Bioanalysis, 2014
Plasma protein binding (PPB) is an important parameter for a drug's efficacy and safety that needs to be investigated during each drug-development program.
B. Buscher, S. Laakso, H. Mascher, K. Pusecker, Mira Doig, L. Dillen, W. Wagner-Redeker, T. Pfeifer, P. Delrat, P. Timmerman   +9 more
semanticscholar   +1 more source

Lidocaine plasma protein binding

Clinical Pharmacology and Therapeutics, 1980
The percent of unbound lidocaine in the plasma of 24 healthy subjects was measured by equilibrium dialysis after addition of 3 microgram/ml C14 lidocaine hydrochloride. The percentage of unbound lidocaine varied from 19.9 to 38.8 (30.2 +/- 5, mean +/- SD) was inversely related to the concentration of alpha 1-acid glycoprotein (AAG) in the plasma (r ...
Barbara B. Kitchell, Thorir D. Bjornsson, David G. Shand, Philip A. Routledge, Aaron Barchowsky   +4 more
openaire   +3 more sources

PLASMA RETINOL‐BINDING PROTEIN*

Annals of the New York Academy of Sciences, 1980
Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein, retinol-binding protein (RBP). A great deal is known about the chemical structure, metabolism, and biological roles of RBP. RBP is a single polypeptide chain with molecular weight close to 20,000.
openaire   +3 more sources

Plasma protein binding of phencyclidine

Clinical Pharmacology and Therapeutics, 1982
In healthy male subjects (n = 12) phencyclidine (PCP) free fraction was 22.0 +/- 2.8 % (mean +/- SD). In male patients with mild to moderate alcoholic liver disease (n = 16) free fraction (23.0 +/- 3.4%) was of the same order as in healthy subjects although age and the concentrations of albumin, bilirubin, and high-density lipoproteins were different ...
William A. Corrigall, H. G. Giles, V Khouw, Edward M. Sellers   +3 more
openaire   +3 more sources

Determination of atypical nonlinear plasma−protein-binding behavior of tigecycline using an in vitro microdialysis technique.

Journal of Pharmacy and Science, 2014
Tigecycline, a novel glycylcycline antibiotic, shows atypical nonlinear plasma-protein-binding behavior using ultrafiltration and ultracentrifugation techniques. The mechanism of such counterintuitive behavior is currently unknown.
J. Mukker, R. Singh, H. Derendorf
semanticscholar   +1 more source