Results 311 to 320 of about 1,940,722 (375)

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

Nanotoxicology, 2012
The binding of proteins to nanoparticles is an important event that can determine the biological effect of nanoparticles in the body. We examined plasma protein binding to gold nanoparticles (5–20 nm) with different surface charge.
Zhou J. Deng, Mingtao Liang, I. Toth, M. Monteiro, R. Minchin   +4 more
semanticscholar   +1 more source

Quantitative structure--plasma protein binding relationships of acidic drugs.

Journal of Pharmacy and Science, 2012
One of the most important factors, affecting significantly the overall pharmacokinetic and pharmacodynamic profile of a drug, is its binding to plasma protein (PPB).
Z. Zhivkova, I. Doytchinova
semanticscholar   +1 more source

Binding Affinities of Thyroxine-Binding Proteins in Turtle Plasma

General and Comparative Endocrinology, 1993
Binding affinities (Ka) for thyroxine (T4) by blood plasma and purified plasma proteins from two turtles, the slider (Trachemys scripta) and snapper (Chelydra serpentina), were compared with those of a human using equilibrium dialysis. The purified T4 binding protein (TBP) from T.
Karen A. Glennemeier, Paul Licht
openaire   +3 more sources

Renin binding proteins in plasma

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1979
Renin is found in mouse plasma as high molecular weight forms, in addition to the fully active 40 000 dalton form. By using freshly 125 I-labelled 40 000 dalton pure submaxillary mouse renin, no binding to plasma proteins was demonstrable. However, unfolding and refolding of the labelled renin by guanidine facilitated binding to specific mouse and ...
Christian Malling, Arne Høj Nielsen, Jens C. Jensenius, Knud Poulsen, Jens Krøll   +4 more
openaire   +3 more sources

Mn₊₊ BINDING BY PLASMA PROTEINS

International Journal of Peptide and Protein Research, 1973
54Mn2+ added to human or rabbit plasma in vitro combines selectively with the albumin fraction. At pH 7.0, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, where n1 = 1 and K1 = 2.4 × 104, the other where n2 = 0.5 and K2 = 0.5 × 103.Zn2+, Ni2+ and Co2+ can compete effectively for these sites.
Arvind K.N. Nandedkar, Clotelle E. Nurse, Felix Friedberg   +2 more
openaire   +3 more sources

The Binding of Urate to Plasma Proteins

1974
Although the etiologic role of microcrystalline monosodium urate monohydrate in the pathogenesis of acute gouty arthritis has been well established, the mechanism by which urate precipitates in joints, soft tissues and the kidneys remains unclear. Some studies have suggested that the solubility of urate is the key factor and that when the solubility of
David S. Campion, James R. Klinenberg, Rodney Bluestone, Michael W. Whitehouse   +3 more
openaire   +3 more sources

Co++ binding by plasma proteins

Bioinorganic Chemistry, 1973
Abstract 50Co++ added to human or rabbit plasmain vitro combines selectively with the albumin fraction. At pH 7.1, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, wheren1 = 2 andK1 = 6.5 × 103, the other wheren2 = 23 andK2 = 1.6 × 102, Mn++ cannot compete for these sites.
Arvind K.N. Nandedkar, Felix Friedberg, Pankaj K. Basu   +2 more
openaire   +2 more sources

Changes in plasma protein binding have little clinical relevance

Clinical pharmacology and therapy, 2002
Clinical Pharmacology & Therapeutics (2002) 71, 115–121; doi: 10.1067/mcp.2002 ...
L. Benet, B. Hoener
semanticscholar   +1 more source

Plasma Steroid-Binding Proteins

Endocrinology and Metabolism Clinics of North America, 1991
Two steroid-binding proteins circulate in plasma, corticosteroid-binding globulin and sex hormone-binding globulin. They both have several different but connected, physiologic functions. Each is the major determinant of the concentration of the physiologically important hormones that they bind.
openaire   +2 more sources

The Significance and Determination of Plasma Protein Binding

, 2012
Drug protein binding can impact both the pharmacokinetics (absorption, distribution and clearance) and pharmacodynamics (receptor/enzyme interaction) of a drug.
A. Damre, K. Iyer
semanticscholar   +1 more source