Results 311 to 320 of about 1,339,631 (349)
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Co++ binding by plasma proteins
Bioinorganic Chemistry, 1973Abstract 50Co++ added to human or rabbit plasmain vitro combines selectively with the albumin fraction. At pH 7.1, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, wheren1 = 2 andK1 = 6.5 × 103, the other wheren2 = 23 andK2 = 1.6 × 102, Mn++ cannot compete for these sites.
Arvind K.N. Nandedkar +2 more
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Analysis of plasma proteins that bind to glycosaminoglycans
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007Glycosaminoglycan-binding proteins, with specific emphasis on dermatan sulfate, have been investigated in human plasma by affinity chromatography, mass spectrometry and Western blotting. Diluted plasma was applied to affinity columns and bound protein was eluted with 500 mM NaCl.
Akio Saito, Hiroshi Munakata
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Binding of levonorgestrel to monkey plasma proteins
Experientia, 19833H-levonorgestrel, a protein progestational steroid, showed a high affinity saturable binding to monkey plasma. Competitive protein binding experiments suggested that the levonorgestrel binds to a protein which resembles sex hormone-binding globulin.
A. K. Srivastava, S. K. Roy
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Determination of Compound Binding to Plasma Proteins
Current Protocols in Pharmacology, 2002AbstractThe pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasma proteins. Consequently, the determination of the plasma protein binding of a compound is essential during drug development and is increasingly required during lead prioritization.
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A binding-protein for aldosterone in human plasma
Journal of Steroid Biochemistry, 1982Equilibrium dialysis of fresh human plasma revealed that aldosterone was bound to plasma proteins other than albumin. The apparent association constant of aldosterone to nonalbumin plasma proteins was one order of magnitude larger than that reported for aldosterone to corticosteroid-binding globulin (CBG), while its binding capacity was smaller than ...
T Yamaji, S Katayama
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Progesterone Binding Plasma Protein (PBP)
Nature, 1970SINCE Seal et al.1 showed that, in the human plasma, the high affinity binding of progesterone is due to the corticosteroid binding globulin (CBG), it has been assumed by most investigators that this is the case in all species and in all conditions.
Michel Atger +2 more
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Determination of the binding of thyroxine to plasma proteins by competitive protein-binding analysis
Clinica Chimica Acta, 1973Abstract Binding capacities for thyroxine-binding globulin (TBG) and thyroxinebinding prealbumin (TBPA) and the equilibrium constants KTBg and Ktbpa were studied by competitive protein-binding techniques. A tracer dose of [ 125 I]thyroxine is equilibrated with the serum.
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Plasma Protein Binding of Challenging Compounds
Journal of Pharmaceutical Sciences, 2015Accurately determining fraction unbound (fu ) with currently available methods has been challenging for certain compounds. Inaccurate fu values can lead to the misinterpretation of important attributes of a drug candidate. Our analysis of over 2000 Pfizer drug discovery compounds showed no systematic bias in low or high fu precision using the ...
Li Di +7 more
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Binding of Ebselen to Plasma Protein
1989Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing het-erocyclic compound, which exhibits GSH peroxidaselike activity in vitro and anti-inflammatory activity in vivo (Muller et al. 1984; Kuhl et al. 1985).
H. Hakusui, T. Takegoshi, H. Nomura
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The Binding of Drugs by Plasma Proteins [PDF]
Journal of Pharmaceutical Sciences, 1968 Marvin C. Meyer, David E. Guttman
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