Results 331 to 340 of about 2,396,679 (391)

The Binding of Urate to Plasma Proteins

1974
Although the etiologic role of microcrystalline monosodium urate monohydrate in the pathogenesis of acute gouty arthritis has been well established, the mechanism by which urate precipitates in joints, soft tissues and the kidneys remains unclear. Some studies have suggested that the solubility of urate is the key factor and that when the solubility of
David S. Campion, James R. Klinenberg, Rodney Bluestone, Michael W. Whitehouse   +3 more
openaire   +3 more sources

Plasma Protein Binding

1992
Drugs used in anesthesia are all bound to a greater or lesser degree to plasma proteins. Plasma protein binding of drugs has a significant effect on their kinetics and dynamics. Variations of normal physiology and diseases affect both the concentrations and affinity of plasma proteins for drugs. This chapter provides a brief discussion of the relevance
openaire   +2 more sources

Co++ binding by plasma proteins

Bioinorganic Chemistry, 1973
Abstract 50Co++ added to human or rabbit plasmain vitro combines selectively with the albumin fraction. At pH 7.1, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, wheren1 = 2 andK1 = 6.5 × 103, the other wheren2 = 23 andK2 = 1.6 × 102, Mn++ cannot compete for these sites.
Arvind K.N. Nandedkar, Felix Friedberg, Pankaj K. Basu   +2 more
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Plasma Steroid-Binding Proteins

Endocrinology and Metabolism Clinics of North America, 1991
Two steroid-binding proteins circulate in plasma, corticosteroid-binding globulin and sex hormone-binding globulin. They both have several different but connected, physiologic functions. Each is the major determinant of the concentration of the physiologically important hormones that they bind.
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The Significance and Determination of Plasma Protein Binding

, 2012
Drug protein binding can impact both the pharmacokinetics (absorption, distribution and clearance) and pharmacodynamics (receptor/enzyme interaction) of a drug.
A. Damre, K. Iyer
semanticscholar   +1 more source

Plasma protein binding in drug discovery and development.

Combinatorial chemistry & high throughput screening, 2010
This review describes methods for quantifying the binding of small molecule drug candidates to plasma proteins and the application of these methods in drug discovery and development.
M. L. Howard, John J. Hill, G. Galluppi, M. McLean   +3 more
semanticscholar   +1 more source

Analysis of plasma proteins that bind to glycosaminoglycans

Biochimica et Biophysica Acta (BBA) - General Subjects, 2007
Glycosaminoglycan-binding proteins, with specific emphasis on dermatan sulfate, have been investigated in human plasma by affinity chromatography, mass spectrometry and Western blotting. Diluted plasma was applied to affinity columns and bound protein was eluted with 500 mM NaCl.
Akio Saito, Hiroshi Munakata
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Binding of levonorgestrel to monkey plasma proteins

Experientia, 1983
3H-levonorgestrel, a protein progestational steroid, showed a high affinity saturable binding to monkey plasma. Competitive protein binding experiments suggested that the levonorgestrel binds to a protein which resembles sex hormone-binding globulin.
A. K. Srivastava, S. K. Roy
openaire   +3 more sources

Numerical solution of nonlinear pharmacokinetic equations: effects of plasma protein binding on drug distribution and elimination.

Journal of Pharmacy and Science, 1971
Numerical methods are described for the solution of the differential equations arising from nonlinear binding of drugs to plasma proteins, assuming one- and two-compartment pharmacokinetic models.
J. J. Coffey, F. J. Bullock, P. Schoenemann   +2 more
semanticscholar   +1 more source

Do we need to optimize plasma protein and tissue binding in drug discovery?

Current Topics in Medicinal Chemistry, 2011
It is a commonly accepted assumption that only unbound drug molecules are available to interact with their targets. In order to achieve high unbound plasma drug concentration, it seems obvious to design compounds with low plasma protein binding ...
Xingrong Liu, Cuiping Chen, C. Hop
semanticscholar   +1 more source