Results 331 to 340 of about 1,940,722 (375)
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Protein‐binding of secretin in human plasma
Acta Physiologica Scandinavica, 1985Protein‐binding of endogenous plasma secretin and of 125I‐labelled secretin incubated with charcoal‐treated plasma examined by gel nitration on a Sephacryl S‐200 Superfine column (16 times 980 mm) showed that secretin in plasma appears both to be bound to at least two different plasma proteins where albumin appears to be the major binding protein, and ...
Per G. Burhol +3 more
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Plasma Protein Binding of Diazepam and Tolbutamide in Chronic Alcoholics
Journal of clinical pharmacology, 1976The increased incidence of drowsiness in hypoalbuminemic patients administered diazepam and more rapid clearance of tolbutamide in cirrhotics may be due to changes in plasma protein binding.
J. Thiessen +3 more
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Determination of Compound Binding to Plasma Proteins
Current Protocols in Pharmacology, 2002AbstractThe pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasma proteins. Consequently, the determination of the plasma protein binding of a compound is essential during drug development and is increasingly required during lead prioritization.
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Clinical pharmacology and therapy, 1970
Plasma protein binding of diphenylhydantoin (DPH) in normal plasma was investigated with an ultrafiltration technique (at room temperature) with the use of 14C‐labeled DPH. DPH was 92.6 per cent bound.
M. Lunde Per Knut +4 more
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Plasma protein binding of diphenylhydantoin (DPH) in normal plasma was investigated with an ultrafiltration technique (at room temperature) with the use of 14C‐labeled DPH. DPH was 92.6 per cent bound.
M. Lunde Per Knut +4 more
semanticscholar +1 more source
Clinical pharmacology and therapy, 1972
The plasma protein binding and the cerebrospinal fluid (CSF)‐plasma ratio of diphenyhydantoin (DPH) was determined in 8 patients with epilepsy treated only with DPH and in steady‐state conditions.
L. Lund, A. Berlin, P. K. Lunde
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The plasma protein binding and the cerebrospinal fluid (CSF)‐plasma ratio of diphenyhydantoin (DPH) was determined in 8 patients with epilepsy treated only with DPH and in steady‐state conditions.
L. Lund, A. Berlin, P. K. Lunde
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Gentamicin binding to serum and plasma proteins
Clinical Pharmacology & Therapeutics, 1978Gentamicin binding to serum proteins was studied by equilibrium dialysis at 37°C and pH 7.4 in the presence of both physiologic and adjusted concentrations of ionized calcium and magnesium. The percentage of bound drug was inversely related to the concentration of these two divalent cations, ranging from 27% bound with no calcium and magnesium present ...
Joan DeFehr +4 more
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Journal of Pharmacy and Science, 1984
The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by equilibrium dialysis.
F. Boudinot, William J. Jusko
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The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by equilibrium dialysis.
F. Boudinot, William J. Jusko
semanticscholar +1 more source
Determination of the binding of thyroxine to plasma proteins by competitive protein-binding analysis
Clinica Chimica Acta, 1973Abstract Binding capacities for thyroxine-binding globulin (TBG) and thyroxinebinding prealbumin (TBPA) and the equilibrium constants KTBg and Ktbpa were studied by competitive protein-binding techniques. A tracer dose of [ 125 I]thyroxine is equilibrated with the serum.
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A binding-protein for aldosterone in human plasma
Journal of Steroid Biochemistry, 1982Equilibrium dialysis of fresh human plasma revealed that aldosterone was bound to plasma proteins other than albumin. The apparent association constant of aldosterone to nonalbumin plasma proteins was one order of magnitude larger than that reported for aldosterone to corticosteroid-binding globulin (CBG), while its binding capacity was smaller than ...
T Yamaji, S Katayama
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Progesterone Binding Plasma Protein (PBP)
Nature, 1970SINCE Seal et al.1 showed that, in the human plasma, the high affinity binding of progesterone is due to the corticosteroid binding globulin (CBG), it has been assumed by most investigators that this is the case in all species and in all conditions.
Michel Atger +2 more
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