Results 341 to 350 of about 2,396,679 (391)
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A binding-protein for aldosterone in human plasma
Journal of Steroid Biochemistry, 1982Equilibrium dialysis of fresh human plasma revealed that aldosterone was bound to plasma proteins other than albumin. The apparent association constant of aldosterone to nonalbumin plasma proteins was one order of magnitude larger than that reported for aldosterone to corticosteroid-binding globulin (CBG), while its binding capacity was smaller than ...
T Yamaji, S Katayama
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Determination of Compound Binding to Plasma Proteins
Current Protocols in Pharmacology, 2002AbstractThe pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasma proteins. Consequently, the determination of the plasma protein binding of a compound is essential during drug development and is increasingly required during lead prioritization.
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Progesterone Binding Plasma Protein (PBP)
Nature, 1970SINCE Seal et al.1 showed that, in the human plasma, the high affinity binding of progesterone is due to the corticosteroid binding globulin (CBG), it has been assumed by most investigators that this is the case in all species and in all conditions.
Michel Atger+2 more
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Determination of the binding of thyroxine to plasma proteins by competitive protein-binding analysis
Clinica Chimica Acta, 1973Abstract Binding capacities for thyroxine-binding globulin (TBG) and thyroxinebinding prealbumin (TBPA) and the equilibrium constants KTBg and Ktbpa were studied by competitive protein-binding techniques. A tracer dose of [ 125 I]thyroxine is equilibrated with the serum.
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Journal of Pharmacy and Science, 1984
The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by equilibrium dialysis.
F. Boudinot, William J. Jusko
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The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by equilibrium dialysis.
F. Boudinot, William J. Jusko
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Techniques for plasma protein binding of demethylchlorimipramine
Clinical Pharmacology & Therapeutics, 1979The cerebrospinal fluid (CSF) and plasma levels of demethylchlorimipramine (DMC1) were determined during treatment of depression or obsessive‐compulsive disorders with chlorimipramine. In 18 patients the mean CSF/plasma ratio of DMCI was 2.6% ± 0.7 SD with fourfold variation (1.1% to 4.0%).
Mats Garle+4 more
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Binding of Ebselen to Plasma Protein
1989Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing het-erocyclic compound, which exhibits GSH peroxidaselike activity in vitro and anti-inflammatory activity in vivo (Muller et al. 1984; Kuhl et al. 1985).
H. Hakusui, T. Takegoshi, H. Nomura
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The Binding of Drugs by Plasma Proteins [PDF]
Marvin C. Meyer, David E. Guttman
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RETINOID‐BINDING PROTEINS IN PLASMA AND IN CELLS*
Annals of the New York Academy of Sciences, 1981Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein, retinol-binding protein (RBP).
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Plasma protein binding of cannabidiol
Phytotherapy Research, 2022Jonathan Lara+2 more
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