Results 341 to 350 of about 2,396,679 (391)

A binding-protein for aldosterone in human plasma

Journal of Steroid Biochemistry, 1982
Equilibrium dialysis of fresh human plasma revealed that aldosterone was bound to plasma proteins other than albumin. The apparent association constant of aldosterone to nonalbumin plasma proteins was one order of magnitude larger than that reported for aldosterone to corticosteroid-binding globulin (CBG), while its binding capacity was smaller than ...
T Yamaji, S Katayama
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Determination of Compound Binding to Plasma Proteins

Current Protocols in Pharmacology, 2002
AbstractThe pharmocokinetic and pharmacodynamic properties of a compound are profoundly affected by the extent of its binding to plasma proteins. Consequently, the determination of the plasma protein binding of a compound is essential during drug development and is increasingly required during lead prioritization.
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Progesterone Binding Plasma Protein (PBP)

Nature, 1970
SINCE Seal et al.1 showed that, in the human plasma, the high affinity binding of progesterone is due to the corticosteroid binding globulin (CBG), it has been assumed by most investigators that this is the case in all species and in all conditions.
Michel Atger, Etienne-Emile Baulieu, Edwin Milgrom   +2 more
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Determination of the binding of thyroxine to plasma proteins by competitive protein-binding analysis

Clinica Chimica Acta, 1973
Abstract Binding capacities for thyroxine-binding globulin (TBG) and thyroxinebinding prealbumin (TBPA) and the equilibrium constants KTBg and Ktbpa were studied by competitive protein-binding techniques. A tracer dose of [ 125 I]thyroxine is equilibrated with the serum.
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Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis.

Journal of Pharmacy and Science, 1984
The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by equilibrium dialysis.
F. Boudinot, William J. Jusko
semanticscholar   +1 more source

Techniques for plasma protein binding of demethylchlorimipramine

Clinical Pharmacology & Therapeutics, 1979
The cerebrospinal fluid (CSF) and plasma levels of demethylchlorimipramine (DMC1) were determined during treatment of depression or obsessive‐compulsive disorders with chlorimipramine. In 18 patients the mean CSF/plasma ratio of DMCI was 2.6% ± 0.7 SD with fourfold variation (1.1% to 4.0%).
Mats Garle, Olof Borgå, Gunnel Tybring, Leif Bertilsson, Robin Braithwaite   +4 more
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Binding of Ebselen to Plasma Protein

1989
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing het-erocyclic compound, which exhibits GSH peroxidaselike activity in vitro and anti-inflammatory activity in vivo (Muller et al. 1984; Kuhl et al. 1985).
H. Hakusui, T. Takegoshi, H. Nomura
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The Binding of Drugs by Plasma Proteins [PDF]

Journal of Pharmaceutical Sciences, 1968
Marvin C. Meyer, David E. Guttman
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RETINOID‐BINDING PROTEINS IN PLASMA AND IN CELLS*

Annals of the New York Academy of Sciences, 1981
Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein, retinol-binding protein (RBP).
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Plasma protein binding of cannabidiol

Phytotherapy Research, 2022
Jonathan Lara, Nathan Schweky, Mariana Babayeva   +2 more
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