Results 31 to 40 of about 1,371,564 (350)

Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings

Molecules, 2022
PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time.
Guru R. Valicherla, Roshan A. Katekar, Shailesh Dadge, Mohammed Riyazuddin, Anees A. Syed, Sandeep K. Singh, Athar Husain, Muhammad Wahajuddin, Jiaur R. Gayen   +8 more
doaj   +1 more source

The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change [PDF]

, 2010
Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of ...
Lee, B. L., Mauldin, Kasuen, Oleszczuk, M., Ryan, R. O., Sykes, B. D.   +4 more
core   +2 more sources

Seminal Plasma Proteins [PDF]

, 2012
The ejaculated semen consists of two major components viz. sperm cells (spermatozoa) and the fluid part obtained after centrifugation called seminal plasma.
P Perumal
core   +2 more sources

Binding Constants of Clinical Drugs and Other Organic Ligands with Human and Mammalian Serum Albumins

Biophysica, 2021
A dataset containing the experimental values of the equilibrium binding constants of clinical drugs, and some other organic ligands with human and mammalian (predominantly bovine) serum albumins, is assembled.
Igor Sedov, Alena Nikiforova, Diliara Khaibrakhmanova   +2 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Study on the interaction between active components from traditional Chinese medicine and plasma proteins

Chemistry Central Journal, 2018
Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years.
Qishu Jiao, Rufeng Wang, Yanyan Jiang, Bin Liu   +3 more
doaj   +1 more source

Retention Behavior of Anticancer Thiosemicarbazides in Biomimetic Chromatographic Systems and In Silico Calculations

Molecules, 2023
Chromatographic methods, apart from in silico ones, are commonly used rapid techniques for the evaluation of certain properties of biologically active compounds used for their prediction of pharmacokinetic processes.
Marek Studziński, Paweł Kozyra, Monika Pitucha, Bogusław Senczyna, Joanna Matysiak   +4 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine

Journal of Chemistry, 2017
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan   +2 more
doaj   +1 more source

Fluorescence Enhancement of Fluorescein Isothiocyanate-Labeled Protein A Caused by Affinity Binding with Immunoglobulin G in Bovine Plasma

Sensors, 2009
Fluorescence enhancement of fluorescein isothiocyanate-labeled protein A (FITC-protein A) caused by the binding with immunoglobulin G (IgG) in bovine plasma was studied. FITC-protein A was immobilized onto a glass surface by covalent bonds.
Kiyotaka Sakai, Takehito Ogawa, Takehiro Miyasaka, Satoka Aoyagi   +3 more
doaj   +1 more source