Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]
, 2014 Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia +6 more
core +3 more sources
Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
Toxins, 2014 Protein binding prevents uremic toxins from removal by conventional extracorporeal therapies leading to accumulation in maintenance dialysis patients. Weakening of the protein binding may enhance the dialytic elimination of these toxins.
Eric Devine +4 more
doaj +1 more source
Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.
Journal of Agricultural and Food Chemistry, 2018 Ochratoxin A (OTA, 0.25 mg/kg body weight) was absorbed rapidly ( Tmax = 0.31-1.88 h) in all avian species (broiler chickens, laying hens, turkeys, and Muscovy ducks) but more slowly in broiler chickens ( Tmax = 1.43-4.63 h).
M. Devreese +4 more
semanticscholar +1 more source
Microalbuminuria is a major determinant of elevated plasma retinol-binding protein 4 in type 2 diabetic patients [PDF]
, 2007 Plasma retinol-binding protein 4 (RBP4) may be a new adipokine linked to obesity-induced insulin resistance and type 2 diabetes. The impact of diabetic nephropathy on plasma RBP4 levels, however, is not known.
Henze, A. +5 more
core +1 more source
VAMP721 conformations unmask an extended motif for K+ channel binding and gating control [PDF]
, 2016 Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins play a major role in membrane fusion and contribute to cell expansion, signaling, and polar growth in plants.
Blatt, Mike R. +4 more
core +2 more sources
Photoaffinity Labeling of Plasma Proteins
Molecules, 2013 Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling.
Masaki Otagiri, Victor Tuan Giam Chuang
doaj +1 more source
Molecules, 2022 PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time.
Guru R. Valicherla +8 more
doaj +1 more source
Transcutaneous application of ultrasound enhances the effects of finasteride in a murine model of androgenic alopecia [PDF]
Ultrasonography, 2022 Purpose The purpose of this study was to evaluate if transcutaneous application of low-intensity ultrasound can locally enhance the effects of finasteride on hair growth in a murine model of androgenic alopecia (AA).
Jaeho Kim +4 more
doaj +1 more source
The hepta-β-glucoside elicitor-binding proteins from legumes represent a putative receptor family [PDF]
, 2000 The ability of legumes to recognize and respond to β-glucan elicitors by synthesizing phytoalexins is consistent with the existence of a membrane-bound β-glucan-binding site.
Ebel, J. +4 more
core +1 more source
Simultaneous determination of human plasma protein binding of bioactive flavonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS [PDF]
, 2013 A simple and selective ultra performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC–ESI-MS/MS) assay was developed for the determination of the human plasma protein binding of four bioactive flavonoids (such as orientin ...
Chen, Hui +9 more
core +2 more sources