Results 41 to 50 of about 1,269,356 (329)
Retargeted adenoviruses for radiation-guided gene delivery [PDF]
, 2016 The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz +54 more
core +2 more sources
Space Layout of Low-entropy Hydration Shells Guides Protein Binding [PDF]
arXiv, 2022 Protein-protein binding enables orderly and lawful biological self-organization, and is therefore considered a miracle of nature. Protein-protein binding is steered by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions.
arxiv
Molecules, 2023 Chromatographic methods, apart from in silico ones, are commonly used rapid techniques for the evaluation of certain properties of biologically active compounds used for their prediction of pharmacokinetic processes.
Marek Studziński +4 more
doaj +1 more source
Hyaluronan-Arginine Enhanced Interaction Emerges from Distinctive Molecular Signature with Improved Electrostatics and Side-Chain Specificity [PDF]
arXiv, 2023 Hyaluronan, a sugar polymer found outside the plasma membrane, is a critical component of the extracellular matrix (ECM) scaffold. Hyaluronan's length and moderate negative charge aid in ECM entanglement and solubility. This allows it to effectively foster gel-like conditions, which are critical for supporting and protecting cells in various tissues ...
arxiv
Specific protein-protein binding in many-component mixtures of proteins [PDF]
Physical Biology v1, 53 (2004), 2003 Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied.
arxiv +1 more source
Journal of Chemistry, 2017 Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice.
Wan Raihana Wan Aasim +2 more
doaj +1 more source
Sensors, 2009 Fluorescence enhancement of fluorescein isothiocyanate-labeled protein A (FITC-protein A) caused by the binding with immunoglobulin G (IgG) in bovine plasma was studied. FITC-protein A was immobilized onto a glass surface by covalent bonds.
Kiyotaka Sakai +3 more
doaj +1 more source
Blood Plasma Exosomes Contain Circulating DNA in Their Crown
Diagnostics, 2022 It is known that circulating DNA (cirDNA) is protected from nuclease activity by proteins that form macromolecular complexes with DNA. In addition, it was previously shown that cirDNA can bind to the outer surface of exosomes.
Oleg Tutanov +5 more
doaj +1 more source
Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. [PDF]
, 1994 Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating
Kane, JP +4 more
core +1 more source
Protein folding and binding can emerge as evolutionary spandrels through structural coupling [PDF]
Proc Natl Acad Sci USA, 112:1797-1802, 2015, 2014 Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interactions evolve in response to changes in the protein's chemical or physical environment (such as the addition of an antibiotic), or when genes duplicate and diverge. Several recent
arxiv +1 more source