Results 61 to 70 of about 2,396,679 (391)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Decreased protein binding of moxifloxacin in patients with sepsis?

GMS Infectious Diseases, 2017
The mean (SD) unbound fraction of moxifloxacin in plasma from patients with severe sepsis or septic shock was determined by ultrafiltration to 85.5±3.0% (range 81.9 and 91.6%) indicating a decreased protein binding of moxifloxacin in this population ...
Dorn, Christoph, Nowak, Hartmuth, Weidemann, Caroline, Martini, Stefan, Zeitlinger, Markus, Adamzik, Michael, Kees, Frieder   +6 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Afonine, Ahearn, Andrew Purkiss, Andrew J. Thompson, Anne J. Ridley, Bokoch, Bonnefoy-Bérard, Boureux, Brad McColl, Chandra, Corey, Dalal, Emsley, Forget, Foster, Ganka Bineva, Guasch, Hancock, Hidalgo-Carcedo, Hoffman, Hogan, Hu, Ismail, Kostelecky, Lebedev, Madigan, McCoy, Michaelson, Morrison, Muslin, Nancy, Neil Q. McDonald, Nicola O’Reilly, Nicolas Reymond, Nishikawa, Nobes, Obsil, Ottmann, O’Reilly, Pacary, Pearce, Peter J. Parker, Pflugrath, Philippe Riou, Quilliam, Riento, Riento, Riou, Ritu Garg, Roberts, Robert J. Cain, Roger George, Svend Kjær, Thorson, Vagin, van Hennik, Wennerberg, Williamson, Yaffe   +58 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Dose Response, Dosimetric, and Metabolic Evaluations of Replacement PFAS Perfluoro-(2,5,8-trimethyl-3,6,9-trioxadodecanoic) Acid (HFPO-TeA)

Toxics, 2023
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes.
Aero Renyer, Krishna Ravindra, Barbara A. Wetmore, Jermaine L. Ford, Michael DeVito, Michael F. Hughes, Leah C. Wehmas, Denise K. MacMillan   +7 more
doaj   +1 more source

Characterization of Binding of Raltegravir to Plasma Proteins [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT The objective of this study was to characterize raltegravir (RAL) binding to albumin and alpha-1-acid glycoprotein (AAG). Unbound and bound RAL were separated by ultrafiltration. The association constant ( K a ) was estimated by a graphical method.
Caroline Barau, Valérie Furlan, Yazdan Yazdanpanah, Jean-Michel Molina, Catherine Fagard, Anne-Marie Taburet, Aurélie Barrail-Tran   +6 more
openaire   +3 more sources

Allosteric modulation of zinc speciation by fatty acids [PDF]

Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J., Stewart, Alan J. S.   +6 more
core   +1 more source

Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels [PDF]

, 1998
Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate
Dang, Yan L., Davidson, Norman, Lester, Henry A., McPhee, Jancy C.   +3 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source