Results 221 to 230 of about 1,320,101 (268)

Doxepin Plasma Levels and Anxiolytic Response

International Pharmacopsychiatry, 2017
A study of 23 patients (16 females, 7 males), diagnosed as suffering from anxiety, was carried out using a flexible dosage regimen of doxepin. Hamilton Anxiety Rating Scale scores were assessed on days 0, 7, 14 and 21 and plasma doxepin and desmethyldoxepin concentrations were analysed from blood samples taken on days 7, 14 and 21 of the trial.
T R, Norman, G D, Burrows, G N, Bianchi, K P, Maguire, J M, Wurm   +4 more
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Duloxetine plasma level and antidepressant response

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019
Major Depressive Disorder (MDD) is associated with a high rate of inadequate treatment response, which is mainly due to the large inter-individual genetic variability in pharmacokinetic and pharmacodynamic targets of antidepressant drugs. Little is still known about the exact association between plasma level of first-line antidepressants and clinical ...
De Donatis, Domenico, Florio, Vincenzo, Porcelli, Stefano, Saria, Alois, Mercolini, Laura, Serretti, Alessandro, Conca, Andreas   +6 more
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Escitalopram plasma levels and antidepressant response

European Neuropsychopharmacology, 2017
Major Depression Disorder (MDD) has a highly variable treatment response due to the large inter-individual variation in the pharmacokinetics and pharmacodynamics of drug treatments. In detail the correlation between plasma level and efficacy has been much debated. Among first-line drugs for MDD, one of the most used is escitalopram.
Florio, Vincenzo, Porcelli, Stefano, Saria, Alois, Serretti, Alessandro, Conca, Andreas   +4 more
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Clozapine response and plasma catecholamines and their metabolites

Psychiatry Research, 1993
The atypical neuroleptic clozapine has an unusual profile of clinical effects and a distinctive spectrum of pharmacological actions. Plasma measures of catecholamines and their metabolites have been used in the past to study the action of typical neuroleptics.
A I, Green, M Y, Alam, J T, Sobieraj, K M, Pappalardo, C, Waternaux, C, Salzman, A F, Schatzberg, J J, Schildkraut   +7 more
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Plasma biopterin levels and tetrahydrobiopterin responsiveness

Molecular Genetics and Metabolism, 2005
Tetrahydrobiopterin (BH4) responsive hyperphenylalaninemia (HPA) with a mutant phenylalanine hydroxylase (PAH) gene was found during neonatal screening for PKU. This study determined blood BH4 and phenylalanine in two patients with hyperphenylalaninemia following oral load with BH4 10 mg/kg. Our patients underwent neonatal screening for PKU, had normal
Haruo, Shintaku, Hiroki, Fujioka, Yoshitomo, Sawada, Minoru, Asada, Tsunekazu, Yamano   +4 more
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Amitriptyline plasma levels and therapeutic response

Clinical Pharmacology & Therapeutics, 1976
Eighteen depressed outpatients were treatedfor 6 wk with amitriptyline. Clinical improvement was monitored using the Hamilton Depression Rating Scale administered by two psychiatrists blind to the tricyclic used for treatment, dosage, and plasma levels.
V E, Ziegler, B T, Co, J R, Taylor, P J, Clayton, J T, Biggs   +4 more
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Nortriptyline plasma levels and therapeutic response

Clinical Pharmacology & Therapeutics, 1976
Eighteen depressed outpatients were treatedfor 6 wk with a mean daily dose of 121 mg of nortriptyline. The mean plasma level was 138 ng/ml during treatment. Therapeutic response was monitored by the Zung Self‐Rating Depression Scale and the Hamilton Depression Scale administrered by two psychiatrists blind to the tricyclic used, dose, and plasma levels.
V E, Ziegler, P J, Clayton, J R, Taylor, B, Tee, J T, Biggs   +4 more
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Haloperidol response and plasma catecholamines and their metabolites

Schizophrenia Research, 1993
Eleven acutely psychotic patients with schizophrenia or schizoaffective disorder underwent a 5-7 day drug-washout period (with lorazepam allowed) prior to participating in a 6-week controlled dose haloperidol trial. Patients were evaluated longitudinally with clinical ratings and with plasma measures of the catecholamines dopamine (pDA) and ...
A I, Green, M Y, Alam, R A, Boshes, C, Waternaux, K M, Pappalardo, M E, Fitzgibbon, M T, Tsuang, J J, Schildkraut   +7 more
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Viloxazine plasma concentrations and clinical response

Journal of Affective Disorders, 1980
Eleven patients suffering from primary depressive illness were treated with 300 mg/d of viloxazine for 29 days. Blood samples were collected at weekly intervals and severity of depression assessed using the Hamilton depression rating scale. Mean plasma viloxazine level for all patients during the trial was 1.20 micrograms/ml and ranged from 0.40 to 2 ...
T R, Norman, G D, Burrows, B M, Davies, K P, Maguire, J M, Wurm   +4 more
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Abnormal Plasma Catecholamine Responses in Acromegalics

The Journal of Clinical Endocrinology & Metabolism, 1979
Plasma dopamine, norepinephrine, and epinephrine responses to bromocriptine (2.5 mg orally) or to LRH (100 microgram iv) were studied in seven acromegalic patients. In contrast to normal men, in whom plasma concentrations of catecholamines decrease markedly, acromegalic subjects fail to show decreases in plasma dopamine, norepinephrine, or epinephrine ...
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